Volumetric 3D assessment of ablation zones after thermal ablation of colorectal liver metastases to improve prediction of local tumor progression.
Purpose: The goal of this study was to develop and evaluate a volumetric three-dimensional (3D) approach to improve the accuracy of ablation margin assessment following thermal ablation of hepatic tumors.Methods: The 3D margin assessment technique was developed to generate the new 3D assessment metr...
| Publicado en: | European Radiology Vol. 29; no. 5; pp. 2698 - 2706 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135662821&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135662821 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2019 vid: 29 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135662821 135662821 NLM30402706 135662821 10.1007/s00330-018-5809-0 NLM30402706 135662821 ppf: 2698 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Volumetric 3D assessment of ablation zones after thermal ablation of colorectal liver metastases to improve prediction of local tumor progression. aug: au: Kaye, Elena A. Cornelis, Francois H. Petre, Elena N. Tyagi, Neelam Shady, Waleed Shi, Weiji Zhang, Zhigang Solomon, Stephen B. Sofocleous, Constantinos T. Durack, Jeremy C. affil: Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room S1212B, 10065, New York, NY, USA sug: subj: Tomography, X-Ray Computed Methods Colorectal Neoplasms Surgery Imaging, Three-Dimensional Methods Liver Neoplasms Surgery Catheter Ablation Methods Adult Treatment Outcomes Colorectal Neoplasms Pathology Male Retrospective Design Liver Neoplasms Diagnosis Liver Neoplasms Aged Disease Progression Aged, 80 and Over Middle Age Prospective Studies Female Funding Source Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Male Female ab: Purpose: The goal of this study was to develop and evaluate a volumetric three-dimensional (3D) approach to improve the accuracy of ablation margin assessment following thermal ablation of hepatic tumors.Methods: The 3D margin assessment technique was developed to generate the new 3D assessment metrics: volumes of insufficient coverage (VICs) measuring volume of tissue at risk post-ablation. VICs were computed for the tumor and tumor plus theoretical 5- and 10-mm margins. The diagnostic accuracy of the 3D assessment to predict 2-year local tumor progression (LTP) was compared to that of manual 2D assessment using retrospective analysis of a patient cohort that has previously been reported as a part of an outcome-centered study. Eighty-six consecutive patients with 108 colorectal cancer liver metastases treated with radiofrequency ablation (2002-2012) were used for evaluation. The 2-year LTP discrimination power was assessed using receiver operating characteristic area under the curve (AUC) analysis.Results: A 3D assessment of margins was successfully completed for 93 out of 108 tumors. The minimum margin size measured using the 3D method had higher discrimination power compared with the 2D method, with an AUC value of 0.893 vs. 0.790 (p = 0.01). The new 5-mm VIC metric had the highest 2-year LTP discrimination power with an AUC value of 0.923 (p = 0.004).Conclusions: Volumetric semi-automated 3D assessment of the ablation zone in the liver is feasible and can improve accuracy of 2-year LTP prediction following thermal ablation of hepatic tumors.Key Points: • More accurate prediction of local tumor progression risk using volumetric 3D ablation zone assessment can help improve the efficacy of image-guided percutaneous thermal ablation of hepatic tumors. • The accuracy of evaluation of ablation zone margins after thermal ablation of colorectal liver metastases can be improved using a volumetric 3D semi-automated assessment approach and the volume of insufficient coverage assessment metric. • The new 5-mm volume-of-insufficient-coverage metric, indicating the volume of tumor plus 5-mm margin that remained untreated, had the highest 2-year local tumor progression discrimination power. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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