Effect of well-controlled gestational diabetes on left ventricular diastolic dysfunction in neonates.
Background: There are some evidences supporting the relation between gestational diabetes mellitus (GDM) and diastolic dysfunction. The aim of our study was to investigate the effect of well-controlled GDM on morphological and functional myocardium.Materials and Methods: We designed a prospective cr...
| Publicado en: | Journal of Maternal-Fetal & Neonatal Medicine Vol. 32; no. 13; pp. 2101 - 2107 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jul2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135672160&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135672160 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14767058 O6A jtl: Journal of Maternal-Fetal & Neonatal Medicine issn: 14767058 maglogo: Y pubinfo: dt: Jul2019 vid: 32 iid: 13 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 135672160 135672160 NLM29911451 10.1080/14767058.2018.1425832 NLM29911451 135672160 ppf: 2101 ppct: 6 formats: tig: atl: Effect of well-controlled gestational diabetes on left ventricular diastolic dysfunction in neonates. aug: au: Ghandi, Yazdan Habibi, Danial Nasri, Khadijeh Alinejad, Saeed Taherahmad, Hassan Arjmand Shabestari, Ali Nematinejad, Ali affil: Amirkabir Hospital, Department of Pediatric Cardiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran sug: subj: Ventricular Dysfunction, Left Etiology Diabetes Mellitus, Gestational Diet Therapy Diabetes Mellitus, Gestational Drug Therapy Heart Hypertrophy Etiology Insulin Cross Sectional Studies Ventricular Dysfunction, Left Metformin Infant, Newborn Echocardiography, Doppler, Pulsed Ventricular Dysfunction, Left Physiopathology Iran Male Pregnancy Adult Heart Hypertrophy Physiopathology Female Prospective Studies Heart Hypertrophy Case Control Studies Hypoglycemic Agents Infant, Newborn: birth-1 month Adult: 19-44 years Male Female ab: Background: There are some evidences supporting the relation between gestational diabetes mellitus (GDM) and diastolic dysfunction. The aim of our study was to investigate the effect of well-controlled GDM on morphological and functional myocardium.Materials and Methods: We designed a prospective cross-sectional study to evaluate left ventricular (LV) diastolic function of 60 neonates born from mothers with well-controlled GDM (case group) on days of 3-5 after birth. The infants of diabetic mothers (IDM) group were divided into two groups: diabetic mothers treated only with diet (class A) and group of mothers on medical therapy by insulin or metformin (class B). Traditional echocardiography and pulsed-wave Doppler (PWD), tissue Doppler imaging (TDI) were performed for all the neonates.Results: The study group consisted of 60 neonates as males (M) = 32, (0.53%) and females (F) = 28, (0.46%). Using M-mode echocardiography, interventricular septum thickness (IVS), and LV mass were significantly higher in IDM than control group (p = .0001). The PWD showed both a significantly more peak mitral flow at early diastolic wave (E) and an early filling deceleration time (E-DT) (p = .0001). Tissue Doppler echocardiography parameters A' (cm/s) (p = .0001), E' (cm/s) (p = .002), and E'/A' ratio (p = .0001), left ventricular myocardial performance index (LVMPI), and isovolumetric relaxation time (IVRT) were outstandingly different between the two groups (p = .0001, respectively). Evaluating the GDM group mothers of class A and class B, no significant difference was noted in PWD or TDI parameters compared with the healthy ones.Conclusions: It seems that neonates of mothers with well-controlled GDM are still at increased risk of cardiac hypertrophy, subclinical diastolic dysfunction, and impaired left ventricular relaxation. This can be interpreted that focusing only on glycemic control is not enough to prevent cardiac dysfunction. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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