Executive Dysfunction in Patients With Korsakoff's Syndrome: A Theory-Driven Approach.
Aims In addition to amnesia, executive deficits are prominent in Korsakoff's syndrome (KS), yet poorly studied. This study investigates the degree of executive dysfunction in patients with KS for the three main executive subcomponents shifting, updating and inhibition using novel, theory-driven para...
| Publicado en: | Alcohol & Alcoholism Vol. 54; no. 1; pp. 23 - 30 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135757430&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135757430 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jan2019 vid: 54 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 135757430 135757430 135757430 10.1093/alcalc/agy078 135757430 ppf: 23 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Executive Dysfunction in Patients With Korsakoff's Syndrome: A Theory-Driven Approach. aug: au: Brink, W G Moerman-van den Aken, L van Verschuur, E M L Walvoort, S J W Egger, J I M Kessels, R P C affil: Korsakoff Center Markenhof, Atlant, Beekbergen, The NetherlandsDonders Institute for Brain, Cognition and Behaviour, Radboud University, Montessorilaan 3, Nijmegen, The Netherlands sug: subj: Korsakoff Syndrome Psychosocial Factors Executive Function Evaluation Cognition Disorders Diagnosis Task Performance and Analysis Human Male Female Middle Age Analysis of Variance Effect Size Medical Practice Middle Aged: 45-64 years Male Female ab: Aims In addition to amnesia, executive deficits are prominent in Korsakoff's syndrome (KS), yet poorly studied. This study investigates the degree of executive dysfunction in patients with KS for the three main executive subcomponents shifting, updating and inhibition using novel, theory-driven paradigms. Short summary Compared to healthy controls, patients with KS show impairments on the executive subcomponents shifting and updating, but not on inhibition. Methods Executive functions were measured with six carefully designed tasks in 36 abstinent patients with KS (mean age 62.3; 28% woman) and compared with 30 healthy non-alcoholic controls (mean age 61.8; 40% woman). ANOVAs were conducted to examine group differences and effect sizes were calculated. Results Compared to healthy controls, patients with KS were impaired on the executive subcomponents shifting and updating. No statistically significant group difference was found on the factor inhibition. Conclusions Executive dysfunction in long-abstinent patients with alcoholic KS shows a profile in which shifting and updating ability are affected most. It also highlights that executive dysfunction is an important feature of KS and requires more attention in scientific and clinical practice, as these deficits may also affect daily functioning. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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