Higher Creatinine Concentrations in Ethyl Glucuronide-Positive Urine Specimens Collected from Subjects in a Controlled Alcohol Abstinence Program: Is Serum Creatinine a Good Marker of Renal Function in Drinkers?
Aims The aim of this study was to examine urine creatinine concentrations in drivers submitted to controlled alcohol abstinence programs. Methods Urine samples (n = 32,210) were screened for ethyl glucuronide (EtG) by immunoassay during a 2-year period. Non-negatives underwent EtG and ethyl sulfate...
| Publicado en: | Alcohol & Alcoholism Vol. 54; no. 1; pp. 19 - 23 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135757432&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135757432 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jan2019 vid: 54 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 135757432 135757432 135757432 10.1093/alcalc/agy084 135757432 ppf: 19 ppct: 4 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Higher Creatinine Concentrations in Ethyl Glucuronide-Positive Urine Specimens Collected from Subjects in a Controlled Alcohol Abstinence Program: Is Serum Creatinine a Good Marker of Renal Function in Drinkers? aug: au: Polettini, Aldo Eliano Bleicher, Sergej Kutzler, Johannes Mauerer, Richard Schultis, Wolfgang affil: Department of Toxicology & Forensic Toxicology, SYNLAB MVZ Weiden GmbH, Zur Kesselschmiede 4, Weiden, GermanyDepartment of Diagnostics & Public Health, University of Verona, Piazzale L.A. Scuro, 10, Verona, Italy sug: subj: Creatinine Urine Acids, Acyclic Urine Creatinine Blood Alcohol Rehabilitation Programs Biological Markers Blood Kidney Function Tests Alcohol Abstinence Human Urinalysis Immunoassay Chromatography, Liquid Methods Mass Spectrometry Methods Street Drugs Ethanol Urine Urination Infant, Newborn Infant Child, Preschool Child Adolescence Young Adult Adult Middle Age Aged Aged, 80 and Over Sex Factors Infant, Newborn: birth-1 month Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over ab: Aims The aim of this study was to examine urine creatinine concentrations in drivers submitted to controlled alcohol abstinence programs. Methods Urine samples (n = 32,210) were screened for ethyl glucuronide (EtG) by immunoassay during a 2-year period. Non-negatives underwent EtG and ethyl sulfate (EtS) confirmation by coupled-column Liquid Chromatography-Tandem Mass Spectrometry. Urine samples were tested for dilution by the analysis of creatinine content with <0.2 g/l indicating a dilute specimen. Results The mean urine creatinine was significantly higher in EtG positives compared to negatives (1.47 ± 0.98 vs. 1.17 ± 0.79 g/l). The difference between positives and negatives was consistent within genders and age groups (<45; ≥45). The higher urinary creatinine in EtG positives is explained by a late antidiuretic effect of alcohol. Conclusion Attempts to dilute urine specimens by drinking water or other liquids before voiding are less effective for EtG/EtS compared with illicit drugs excreted in urine. If the temporary decrease in serum creatinine as a consequence of the late antidiuretic effect of alcohol is confirmed by controlled studies, serum creatinine as an indicator of kidney function should be reconsidered in drinkers. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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