Review of Different Sequence Motif Finding Algorithms.

The DNA motif discovery is a primary step in many systems for studying gene function. Motif discovery plays a vital role in identification of Transcription Factor Binding Sites (TFBSs) that help in learning the mechanisms for regulation of gene expression. Over the past decades, different algorithms...

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Publicado en:Avicenna Journal of Medical Biotechnology Vol. 11; no. 2; pp. 130 - 149
Autores principales: Hashim, Fatma A., Mabrouk, Mai S., Al-Atabany, Walid
Formato: equations & formulas review tables/charts Journal Article
Publicado: Avicenna Research Institute 2019
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Review of Different Sequence Motif Finding Algorithms.
      aug:
        au:
          Hashim, Fatma A.
          Mabrouk, Mai S.
          Al-Atabany, Walid
        affil: Department of Biomedical Engineering, Helwan University, Egypt
      sug:
        subj:
          DNA Fingerprinting Methods
          Algorithms Utilization
          Algorithms Classification
          Sequence Analysis Methods
          Transcription Factors
          Gene Expression
          Bioinformatics
          Consensus
          Nucleotide Mapping
          DNA-Binding Proteins
      ab: The DNA motif discovery is a primary step in many systems for studying gene function. Motif discovery plays a vital role in identification of Transcription Factor Binding Sites (TFBSs) that help in learning the mechanisms for regulation of gene expression. Over the past decades, different algorithms were used to design fast and accurate motif discovery tools. These algorithms are generally classified into consensus or probabilistic approaches that many of them are time-consuming and easily trapped in a local optimum. Nature-inspired algorithms and many of combinatorial algorithms are recently proposed to overcome these problems. This paper presents a general classification of motif discovery algorithms with new sub-categories that facilitate building a successful motif discovery algorithm. It also presents a summary of comparison between them.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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