A High Degree of Dyspnea Is Associated With Poor Maximum Exercise Capacity in Subjects With COPD With the Same Severity of Air-Flow Obstruction.
BACKGROUND: In patients with COPD, limited data have been reported concerning the association between dyspnea perception and exercise tests. Moreover, the perception of dyspnea has not been analyzed in patients with the same severity of air-flow obstruction. The aim of our study was to evaluate the...
| Publicado en: | Respiratory Care Vol. 64; no. 4; pp. 390 - 398 |
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| Autores principales: | , , , , , , , |
| Formato: | CEU research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135791613&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135791613 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Apr2019 vid: 64 iid: 4 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 135791613 135791613 135791613 10.4187/respcare.06336 135791613 ppf: 390 ppct: 8 formats: fmt: @attributes: type: P tig: atl: A High Degree of Dyspnea Is Associated With Poor Maximum Exercise Capacity in Subjects With COPD With the Same Severity of Air-Flow Obstruction. aug: au: Crisafulli, Ernesto Aiello, Marina Tzani, Panagiota Ielpo, Antonella Longo, Chiara Alfieri, Veronica Bertorelli, Giuseppina Chetta, Alfredo affil: Respiratory Disease and Lung Function Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy sug: subj: Dyspnea Risk Factors Pulmonary Disease, Chronic Obstructive Physiopathology Airway Obstruction Complications Exercise Test, Cardiopulmonary Oxygen Consumption Human Education, Continuing (Credit) Prospective Studies Nonexperimental Studies Italy Academic Medical Centers Respiratory Function Tests Spirometry Lung Physiopathology Descriptive Statistics Goodness of Fit Chi Square Test Fisher's Exact Test T-Tests Mann-Whitney U Test Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient Linear Regression Confidence Intervals Data Analysis Software Male Female Middle Age Aged Questionnaires Middle Aged: 45-64 years Aged: 65+ years Male Female ab: BACKGROUND: In patients with COPD, limited data have been reported concerning the association between dyspnea perception and exercise tests. Moreover, the perception of dyspnea has not been analyzed in patients with the same severity of air-flow obstruction. The aim of our study was to evaluate the relationship between the degree of dyspnea and exercise capacity in subjects with COPD who had the same severity of air-flow obstruction. METHODS: We assessed dyspnea perception and maximum exercise capacity by using the modified Medical Research Council dyspnea scale (mMRC) questionnaire and by using the symptom-limited incremental cardiopulmonary exercise test, respectively. A propensity score matching was used to obtain the balance between the subjects with COPD and with an mMRC questionnaire score <2 and >2 (mMRC score) according to the severity of air-flow obstruction. RESULTS: A total of 249 ambulatory adult patients with stable COPD (mean age, 68 y) were considered in the full cohort. After propensity score analysis, 160 subjects (65% men; mean ± SD FEV1, 47.5 ± 12.8% of predicted) were included in our study cohort. The subjects with an mMRC questionnaire score ≥2 in comparison with those with an mMRC questionnaire score <2 showed lower values in oxygen uptake at peak (V... max) (P = .002) and in maximum work load (P < .001). In the regression models, the mMRC questionnaire score was able to predict oxygen uptake at peak (P < .001) and at maximum work load (P < .001). CONCLUSIONS: In subjects with COPD and with the same severity of air-flow obstruction, a high score in dyspnea was related to a poor maximum exercise capacity. Our results support the view that, in COPD, the severity of air-flow obstruction was less informative than symptoms in the combined assessment of the disease. pubtype: Academic Journal doctype: CEU research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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