Evidence for non-Newtonian behavior of intracranial blood flow from Doppler ultrasonography measurements.
Computational fluid dynamics (CFD) studies of intracranial hemodynamics often use Newtonian viscosity model to close the shear rate term in the Navier-Stokes equation. This is based on a commonly accepted hypothesis which state that non-Newtonian effects can be neglected in intracranial blood flow....
| Publicado en: | Medical & Biological Engineering & Computing Vol. 57; no. 5; pp. 1029 - 1037 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135997065&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135997065 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: May2019 vid: 57 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135997065 135997065 NLM30523533 10.1007/s11517-018-1926-9 NLM30523533 135997065 ppf: 1029 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Evidence for non-Newtonian behavior of intracranial blood flow from Doppler ultrasonography measurements. aug: au: Saqr, Khalid M. Mansour, Ossama Tupin, Simon Hassan, Tamer Ohta, Makoto affil: Biomedical Flow Dynamics Laboratory, Institute of Fluid Science, Tohoku University, 980-8577, Sendai, Miyagi, Japan sug: subj: Cerebrovascular Circulation Physiology Ultrasonography, Doppler Methods Carotid Arteries Models, Biological Cerebral Arteries Middle Age Ultrasonography, Doppler Statistics and Numerical Data Male Blood Flow Velocity Physiology Hemodynamics Female Middle Cerebral Artery Arthritis Impact Measurement Scales Middle Aged: 45-64 years Male Female ab: Computational fluid dynamics (CFD) studies of intracranial hemodynamics often use Newtonian viscosity model to close the shear rate term in the Navier-Stokes equation. This is based on a commonly accepted hypothesis which state that non-Newtonian effects can be neglected in intracranial blood flow. This study aims to examine the validity of such hypothesis to guide future CFD studies of intracranial hemodynamics. Doppler ultrasonography (DUS) measurements of systolic and diastolic vessel diameter and blood velocity were conducted on 16 subjects (mean age 50.6). The measurements were conducted on the internal carotid (ICA), middle cerebral (MCA), and anterior communicating (AComA) arteries. Systolic and diastolic wall shear stress (WSS) values were calculated via the Hagen-Poiseuille exact solution using Newtonian and three different non-Newtonian models: namely Carreau, power-law and Herschel-Bulkley models. The Weissenberg-Rabinowitsch correction for blood shear-thinning viscosity was applied to the non-Newtonian models. The error percentage between the two sets of models was calculated and discussed. The Newtonian hypothesis was tested statistically and discussed using paired t tests. Significant differences (P < 0.0001) were found between the Newtonian and non-Newtonian WSS in ICA. In MCA and AComA, similar differences were found except in the systole and diastole for the Herschel-Bulkley and power-law models (P = 0.0669, P = 0.7298), respectively. The error between the Newtonian and non-Newtonian models ranged from - 27 to 30% (0.2 to 2.2 Pa). These values could affect the physical interpretation of IA CFD studies. Evidence suggests that the Newtonian assumption may be inappropriate to investigate intracranial hemodynamics. Graphical abstract The WSS estimation error resulting from using the Newtonian assumption compared to three non-Newtonian models for ICA, MCA, and AComA in systole and diastole conditions, based on TCCD measurements of 16 subjects. The error due to the Newtonian assumption ranged from 0.2 to 2.2 Pa (- 27 to 30%). These values could affect the physical interpretation of IA CFD studies. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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