Models for optimally controlling varicella and herpes zoster by varicella vaccination: a comparative study.
The introduction of mass vaccination against Varicella-Zoster-Virus (VZV) is being delayed in many European countries mainly because of the "fear" of a subsequent boom in natural herpes zoster (HZ) incidence in the first decades after the initiation of vaccination, caused by the expected decline in...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 57; no. 5; pp. 1121 - 1133 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
May2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135997070&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135997070 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: May2019 vid: 57 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135997070 135997070 NLM30652233 135997070 10.1007/s11517-018-1938-5 NLM30652233 135997070 ppf: 1121 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Models for optimally controlling varicella and herpes zoster by varicella vaccination: a comparative study. aug: au: Betta, Monica Landi, Alberto Manfredi, Piero Laurino, Marco affil: IMT School for Advanced Studies, Piazza S. Francesco 19, 55100, Lucca, Italy sug: subj: Herpes Zoster Epidemiology Chickenpox Prevention and Control Chickenpox Vaccine Therapeutic Use Adolescence Chickenpox Epidemiology Models, Theoretical Human Adult Child Herpes Zoster Prevention and Control Herpes Zoster Transmission Aged Middle Age Immunization Programs Statistics and Numerical Data Validation Studies Comparative Studies Evaluation Research Multicenter Studies Ways of Coping Questionnaire Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Aged: 65+ years Middle Aged: 45-64 years ab: The introduction of mass vaccination against Varicella-Zoster-Virus (VZV) is being delayed in many European countries mainly because of the "fear" of a subsequent boom in natural herpes zoster (HZ) incidence in the first decades after the initiation of vaccination, caused by the expected decline in the protective effect of natural immunity boosting due to reduced virus circulation. Optimal control theory has proven to be a successful tool in understanding ways to curtail the spread of infectious diseases by devising the optimal disease intervention strategies. In this paper, we describe how a reduced 'toy' model can extract the essentials of the dynamics of the VZV transmission and reactivation in case of the study of optimal paths of varicella immunization programs. Results obtained using different optimization approaches are compared with the ones of a more realistic age-structured model. The reduced model shows some unreliable predictions in regards of model time scales about herpes zoster dynamic; nevertheless, it is able to reproduce the main qualitative dynamic of the more realistic model to the different optimization problems, while requiring a minimal number of parameters to be identified. Graphical abstract ᅟ. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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