Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex.
The mesocorticolimbic dopamine (DA) circuit, comprising the mesolimbic and mesocortical DA pathways, plays a crucial role in reward, cognitive control, and motivation. The positron emission tomography (PET) radiotracer, [C-11]raclopride, has been used widely to image DA receptors and DA changes in t...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 2; pp. 314 - 323 |
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| Autores principales: | , , , |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136128840&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136128840 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2019 vid: 13 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136128840 136128840 NLM29071465 136128840 10.1007/s11682-017-9779-7 NLM29071465 136128840 ppf: 314 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex. aug: au: Liu, Heather Zakiniaeiz, Yasmin Cosgrove, Kelly P. Morris, Evan D. affil: Department of Biomedical Engineering, Yale University, New Haven, CT, USA sug: subj: Cerebral Cortex Dopamine Metabolism Basal Ganglia Metabolism Basal Ganglia Tomography, Emission-Computed Methods Cerebral Cortex Metabolism Benzamides Smoking Basal Ganglia Drug Effects Sex Factors Radiopharmaceuticals Cerebral Cortex Drug Effects ab: The mesocorticolimbic dopamine (DA) circuit, comprising the mesolimbic and mesocortical DA pathways, plays a crucial role in reward, cognitive control, and motivation. The positron emission tomography (PET) radiotracer, [C-11]raclopride, has been used widely to image DA receptors and DA changes in the mesolimbic pathway before and after pharmacological and behavioral challenges. In certain circumstances, properties of traditional kinetic models-used to analyze dynamic PET data-are not well-suited to describing the effects of stimulus-induced DA release. To combat model shortcomings, the authors have advanced a suite of models that characterizes PET data in the presence of time-varying DA release. We review select [C-11]raclopride studies of the striatum during cigarette smoking to illustrate the advantages of such models. DA receptors occur in lower density in the cortex than the striatum. This, as well as higher relative background signal, poses a serious challenge to quantitative PET of DA changes in the mesocortical system. Novel high affinity radioligands [F-18]fallypride and [C-11]FLB457 have been used to image mesocortical DA transmission. Models with time-varying terms may also hold the key to optimizing sensitivity to changes in mesocortical DA. As an illustration, we compare recent PET studies of the effect of stress on cortical DA release. Finally, we consider some challenges and strategies for further optimization of sensitivity of PET to stimulus-induced DA changes throughout the whole brain. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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