Altered structural brain connectivity involving the dorsal and ventral language pathways in 16p11.2 deletion syndrome.
Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 2; pp. 430 - 446 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136128847&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136128847 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2019 vid: 13 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136128847 136128847 NLM29629500 10.1007/s11682-018-9859-3 NLM29629500 136128847 ppf: 430 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered structural brain connectivity involving the dorsal and ventral language pathways in 16p11.2 deletion syndrome. aug: au: Ahtam, Banu Link, Naira Hoff, Erikson Ellen Grant, P. Im, Kiho affil: Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Harvard Medical School, 1 Autumn St, 02215, Boston, MA, USA sug: subj: Language Mutation Autism Spectrum Disorder Brain Mapping Chromosome Disorders Neural Pathways Brain Pathology Intellectual Disability Chromosomes Magnetic Resonance Imaging Methods Male Adolescence Image Interpretation, Computer Assisted Methods Child Female Scales Short Portable Mental Status Questionnaire Adolescent: 13-18 years Child: 6-12 years Male Female ab: Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion syndrome (patients: N = 21, age range: 8-16 years; typically developing (TD) controls: 18, 9-16 years) using structural and diffusion MRI. We performed global short-, middle-, long-range, and interhemispheric connectivity analysis in the whole brain using gyral topology-based cortical parcellation. Using region of interest analysis, we studied bilateral dorsal (3 segments of arcuate fasciculus (AF)) and ventral (inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF)) language pathways. Our results showed significantly increased axial (AD) and radial (RD) diffusivities in bilateral anterior AF, decreased volume for left long AF, increased mean diffusivity (MD) and RD for right long AF, and increased AD for bilateral UF in the 16p11.2 deletion group in the absence of significant abnormalities in the whole-brain gyral and interhemispheric connectivity. The selective involvement of the language networks may aid in understanding effects of altered white matter connectivity on neurodevelopmental outcomes in 16p11.2 deletion. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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