Abnormalities in thalamo-cortical connections in patients with first-episode schizophrenia: a two-tensor tractography study.
The "cognitive dysmetria" hypothesis suggests that impairments in cognition and behavior in patients with schizophrenia can be explained by disruptions in the cortico-cerebellar-thalamic-cortical circuit. In this study we examine thalamo-cortical connections in patients with first-episode schizophre...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 2; pp. 472 - 482 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136128848&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136128848 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2019 vid: 13 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136128848 136128848 NLM29667043 10.1007/s11682-018-9862-8 NLM29667043 136128848 ppf: 472 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Abnormalities in thalamo-cortical connections in patients with first-episode schizophrenia: a two-tensor tractography study. aug: au: Hamoda, Hesham M. Makhlouf, A. T. Fitzsimmons, J. Rathi, Y. Makris, N. Mesholam-Gately, R. I. Wojcik, J. D. Goldstein, J. McCarley, R. W. Seidman, L. J. Kubicki, M. Shenton, M. E. affil: Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA, USA sug: subj: Magnetic Resonance Imaging Methods Schizophrenia Pathology Brain Pathology Thalamus Pathology Image Processing, Computer Assisted Young Adult Limbic System Pathology Adult Male Cross Sectional Studies Frontal Lobe Pathology Female Scales Adult: 19-44 years Male Female ab: The "cognitive dysmetria" hypothesis suggests that impairments in cognition and behavior in patients with schizophrenia can be explained by disruptions in the cortico-cerebellar-thalamic-cortical circuit. In this study we examine thalamo-cortical connections in patients with first-episode schizophrenia (FESZ). White matter pathways are investigated that connect the thalamus with three frontal cortex regions including the anterior cingulate cortex (ACC), ventrolateral prefrontal cortex (VLPFC), and lateral oribitofrontal cortex (LOFC). We use a novel method of two-tensor tractography in 26 patients with FESZ compared to 31 healthy controls (HC), who did not differ on age, sex, or education. Dependent measures were fractional anisotropy (FA), Axial Diffusivity (AD), and Radial Diffusivity (RD). Subjects were also assessed using clinical functioning measures including the Global Assessment of Functioning (GAF) Scale, the Global Social Functioning Scale (GF: Social), and the Global Role Functioning Scale (GF: Role). FESZ patients showed decreased FA in the right thalamus-right ACC and right-thalamus-right LOFC pathways compared to healthy controls (HCs). In the right thalamus-right VLPFC tract, we found decreased FA and increased RD in the FESZ group compared to HCs. After correcting for multiple comparisons, reductions in FA in the right thalamus- right ACC and the right thalamus- right VLPC tracts remained significant. Moreover, reductions in FA were significantly associated with lower global functioning scores as well as lower social and role functioning scores. We report the first diffusion tensor imaging study of white matter pathways connecting the thalamus to three frontal regions. Findings of white matter alterations and clinical associations in the thalamic-cortical component of the cortico-cerebellar-thalamic-cortical circuit in patients with FESZ support the cognitive dysmetria hypothesis and further suggest the possible involvement of myelin sheath pathology and axonal membrane disruption in the pathogenesis of the disorder. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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