Regional entropy of functional imaging signals varies differently in sensory and cognitive systems during propofol-modulated loss and return of behavioral responsiveness.
The level and richness of consciousness depend on information integration in the brain. Altered interregional functional interactions may indicate disrupted information integration during anesthetic-induced unconsciousness. How anesthetics modulate the amount of information in various brain regions...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 2; pp. 514 - 526 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136128858&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136128858 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2019 vid: 13 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136128858 136128858 NLM29737490 10.1007/s11682-018-9886-0 NLM29737490 136128858 ppf: 514 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Regional entropy of functional imaging signals varies differently in sensory and cognitive systems during propofol-modulated loss and return of behavioral responsiveness. aug: au: Liu, Xiaolin Lauer, Kathryn K. Ward, B. Douglas Roberts, Christopher J. Liu, Suyan Gollapudy, Suneeta Rohloff, Robert Gross, William Xu, Zhan Chen, Shanshan Wang, Lubin Yang, Zheng Li, Shi-Jiang Binder, Jeffrey R. Hudetz, Anthony G. affil: Department of Radiology, Center for Imaging Research, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, WI, USA sug: subj: Brain Drug Effects Hypnotics and Sedatives Administration and Dosage Image Processing, Computer Assisted Methods Neural Pathways Drug Effects Physics Propofol Administration and Dosage Wakefulness Physiology Magnetic Resonance Imaging Methods Consciousness Wakefulness Drug Effects Sedation Adult Male Unconsciousness Chemically Induced Female Clinical Assessment Tools Scales Adult: 19-44 years Male Female ab: The level and richness of consciousness depend on information integration in the brain. Altered interregional functional interactions may indicate disrupted information integration during anesthetic-induced unconsciousness. How anesthetics modulate the amount of information in various brain regions has received less attention. Here, we propose a novel approach to quantify regional information content in the brain by the entropy of the principal components of regional blood oxygen-dependent imaging signals during graded propofol sedation. Fifteen healthy individuals underwent resting-state scans in wakeful baseline, light sedation (conscious), deep sedation (unconscious), and recovery (conscious). Light sedation characterized by lethargic behavioral responses was associated with global reduction of entropy in the brain. Deep sedation with completely suppressed overt responsiveness was associated with further reductions of entropy in sensory (primary and higher sensory plus orbital prefrontal cortices) but not high-order cognitive (dorsal and medial prefrontal, cingulate, parietotemporal cortices and hippocampal areas) systems. Upon recovery of responsiveness, entropy was restored in the sensory but not in high-order cognitive systems. These findings provide novel evidence for a reduction of information content of the brain as a potential systems-level mechanism of reduced consciousness during propofol anesthesia. The differential changes of entropy in the sensory and high-order cognitive systems associated with losing and regaining overt responsiveness are consistent with the notion of "disconnected consciousness", in which a complete sensory-motor disconnection from the environment occurs with preserved internal mentation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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