A decade of changes in brain volume and cognition.
Brain atrophy can occur several decades prior to onset of cognitive impairments. However, few longitudinal studies have examined the relationship between brain volume changes and cognition over a long follow-up period in healthy elderly women. In the present study we investigate the relationship bet...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 2; pp. 554 - 564 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136128859&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136128859 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Apr2019 vid: 13 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136128859 136128859 NLM29744801 10.1007/s11682-018-9887-z NLM29744801 136128859 ppf: 554 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A decade of changes in brain volume and cognition. aug: au: Aljondi, Rowa Szoeke, Cassandra Steward, Chris Yates, Paul Desmond, Patricia affil: Department of Radiology, The University of Melbourne, Royal Melbourne Hospital, 3050, Parkville, Victoria, Australia sug: subj: Aging Physiology Gray Matter Pathology Hippocampus Pathology Brain Physiopathology Aging Psychosocial Factors Atrophy Pathology Cognition Middle Age Research Subjects Memory Prospective Studies Executive Function Female Middle Aged: 45-64 years Female ab: Brain atrophy can occur several decades prior to onset of cognitive impairments. However, few longitudinal studies have examined the relationship between brain volume changes and cognition over a long follow-up period in healthy elderly women. In the present study we investigate the relationship between whole brain and hippocampal atrophy rates and longitudinal changes in cognition, including verbal episodic memory and executive function, in older women. We also examine whether baseline brain volume predicts subsequent changes in cognitive performance over a 10-year period. A total of 60 individuals from the population-based Women's Healthy Ageing Project with a mean age at baseline of 59 years underwent 3T MRI. Of these, 40 women completed follow-up cognitive assessments, 23 of whom had follow-up MRI scans. Linear regression analysis was used to examine the relationship between brain atrophy and changes in verbal episodic memory and executive function over a 10-year period. The results show that baseline measurements of frontal and temporal grey matter volumes predict changes in verbal episodic memory performance, whereas hippocampal volume at baseline is associated with changes in executive function performance over a 10-year period of follow-ups. In addition, higher whole brain and hippocampal atrophy rates are correlated with a decline in verbal episodic memory. These findings indicate that in addition to atrophy rate, smaller regional grey matter volumes even 10 years prior is associated with increased rates of cognitive decline. This study suggests useful neuroimaging biomarkers for the prediction of cognitive decline in healthy elderly women. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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