Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects.
Backgound: Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. Objective: To evaluate the effects of 4-week theobromine consumption (500 mg/day)...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 3; pp. 981 - 988 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136223441&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136223441 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2019 vid: 58 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136223441 136223441 136223441 10.1007/s00394-018-1612-6 136223441 ppf: 981 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects. aug: au: Smolders, Lotte Mensink, Ronald P. van den Driessche, Jose J. Joris, Peter J. Plat, Jogchum affil: Department of Human Biology and Movement Sciences, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, P.O. Box 616, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands sug: subj: Theobromine Pharmacodynamics Fasting Drug Effects Postprandial Period Drug Effects Biological Markers Drug Effects Blood Vessels Drug Effects Obesity Theobromine Administration and Dosage Human Randomized Controlled Trials Male Female Lipoproteins, HDL Cholesterol Blood Dilatation Manometry Methods Arteries Physiopathology Pulse Wave Velocity Blood Vessels Retina Pathology Meals Scales Systolic Pressure Diastolic Pressure Heart Rate Endothelium Cacao Male Female ab: Backgound: Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. Objective: To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial vascular function markers. Design: In a randomized, double-blind crossover study, 44 apparently healthy overweight (N = 30) and obese (N = 14) men and women with low HDL-C concentrations, consumed daily 500 mg theobromine or placebo for 4 weeks. After 4 weeks, FMD, peripheral arterial tonometry (PAT), augmentation index (AIx), pulse wave velocity (PWV), blood pressure (BP) and retinal microvasculature measurements were performed. These measurements were carried out under fasting conditions and 2.5 h after a high-fat mixed meal challenge. Results: 4-week theobromine consumption did not change fasting vascular function markers, except for a decrease in central AIx (cAIx, − 1.7 pp, P = 0.037) and a trend towards smaller venular calibers (− 2 µm, P = 0.074). Consuming a high-fat mixed meal decreased FMD (0.89 pp, P = 0.002), reactive hyperemia index (RHI, − 0.30, P < 0.001), peripheral systolic BP (SBP, − 3 mmHg, P ≤ 0.001), peripheral diastolic BP (DBP, − 2 mmHg, P ≤ 0.001), central SBP (− 6 mmHg, P ≤ 0.001) and central DBP (− 2 mmHg, P ≤ 0.001), but increased heart rate (HR, 2 bpm, P < 0.001). Theobromine did not modify these postprandial effects, but increased postprandially the brachial artery diameter (0.03 cm, P = 0.015), and decreased the cAIx corrected for a HR of 75 (cAIx75, − 5.0 pp, P = 0.004) and peripheral AIx (pAIx, − 6.3 pp, P = 0.017). Conclusion: Theobromine consumption did not improve fasting and postprandial endothelial function, but increased postprandial peripheral arterial diameters and decreased the AIx. These findings do not suggest that theobromine alone contributes to the proposed cardioprotective effects of cocoa. This trial was registered on clinicaltrials.gov under study number NCT02209025. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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