Administration of Lactobacillus plantarum Lp62 to dam rats at the end of delivery and during lactation affects TGF-β1 level and nutritional milk composition, and body weight of pups.
Purpose: Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat's pups; on yield, cytokines and milk composition was studied. Methods: Lact...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 3; pp. 1137 - 1147 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136223452&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136223452 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2019 vid: 58 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136223452 136223452 136223452 10.1007/s00394-018-1628-y 136223452 ppf: 1137 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Administration of Lactobacillus plantarum Lp62 to dam rats at the end of delivery and during lactation affects TGF-β1 level and nutritional milk composition, and body weight of pups. aug: au: Messias, Gladistone Correia Rocha, Ana Marta Novais Santos, Beatriz Manuela Silva Botelho, Ana Marques Silva, Dhaísa Cristhina Alves Porto, Erika Santos dos Anjos, Marina Lima Sousa, Rayra Almeida Silva, Mara Viana da Rocha, Thainara Barros de Melo, Aracely Vieira Carneiro, Manoela Rios Trindade Aguiar, Nayonara Santana Santos, Patrícia Prado de Souza, Erika Pereira Cruz, Mariluze Peixoto Marques, Lucas Miranda Yatsuda, Regiane Rezende, Raquel Passos Romano, Carla Cristina affil: Multidisciplinary Institute for Health, Federal University of Bahia, Vitória da Conquista, Bahia, Brazil sug: subj: Lactobacillus Probiotics Administration and Dosage Probiotics Pharmacodynamics Lactation Drug Effects Body Weight Drug Effects Transforming Growth Factor beta Drug Effects Cytokines Drug Effects Animal Studies Rats Administration, Oral Triglycerides Blood Cholesterol Blood Lactose Blood Colorimetry Proteins Blood Enzyme-Linked Immunosorbent Assay Breast Analysis Histological Techniques Dietary Supplementation Nutrition ab: Purpose: Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans and exhibited probiotic potential. The influence of oral administration of L. plantarum Lp62 on the growth of rat's pups; on yield, cytokines and milk composition was studied. Methods: Lactobacillus plantarum Lp62 is a lactic acid bacteria strain that has been isolated from cocoa beans. It was administered daily by gavage to Wistar rats (n = 8), from the 7th day before delivery and for 20 days during lactation, in a concentration of 1.44 × 109 CFU/rat. The dam and pups were weighed and milk was collected at 12th and 19th day for determination of protein, triglycerides, cholesterol and lactose by colorimetric assays. TGF-β1 milk levels were analyzed by ELISA. The mammary glands of rats were removed for histological analysis. To detect statistical differences between the groups, tests of mean differences at a significance level of 5% was performed. Results: Supplementation with L. plantarum L62 resulted in significant higher weight of pups (p < 0.05), with similar weight on dams (p > 0.05). The milk yield was not altered by L. plantarum treatment, but the levels of protein, triglycerides and cholesterol were increased (p < 0.05), with no difference in lactose concentration (p > 0.05). Levels of TGF-β1 were higher in the milk of L. plantarum treatment (p < 0.05). Conclusions: The treatment of dams at the end of pregnancy and lactation with L. plantarum Lp62 increased nutritional content of milk, probably contributing to the higher weight of the pups. The higher levels of TGF-β1 in the milk, could promote immune benefits to the pups. Further studies in this field are needed to prove the potential use of L. plantarum Lp62 as a probiotic. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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