Metabolic phenotyping of malnutrition during the first 1000 days of life.
Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously measures a diverse range of low molecular weight...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 3; pp. 909 - 931 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136223471&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136223471 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2019 vid: 58 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136223471 136223471 136223471 10.1007/s00394-018-1679-0 136223471 ppf: 909 ppct: 22 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Metabolic phenotyping of malnutrition during the first 1000 days of life. aug: au: Mayneris-Perxachs, Jordi Swann, Jonathan R. affil: Unit of Nutrition and Health and Unit of Omics Sciences, Eurecat-Technology Centre of Catalonia, Avinguda Universitat 1, 43204, Reus, Spain sug: subj: Phenotype Malnutrition Diagnosis Malnutrition Familial and Genetic Metabolomics Child, Preschool Cognition Child Development Biochemical Phenomena Acute Disease Chronic Disease Micronutrients Energy Metabolism Amino Acids Metabolism Bile Acids and Salts Metabolism Gut Microbiota Biological Markers Developmental Disabilities Risk Factors Child, Preschool: 2-5 years ab: Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously measures a diverse range of low molecular weight metabolites in a sample providing a comprehensive assessment of the individual's biochemical status. There are a growing number of studies applying such approaches to characterize the metabolic derangements induced by various forms of early-life malnutrition. This includes acute and chronic undernutrition and specific micronutrient deficiencies. Collectively, these studies highlight the diverse and dynamic metabolic disruptions resulting from various forms of nutritional deficiencies. Perturbations were observed in many pathways including those involved in energy, amino acid, and bile acid metabolism, the metabolic interactions between the gut microbiota and the host, and changes in metabolites associated with gut health. The information gleaned from such studies provides novel insights into the mechanisms linking malnutrition with developmental impairments and assists in the elucidation of candidate biomarkers to identify individuals at risk of developmental shortfalls. As the metabolic profile represents a snapshot of the biochemical status of an individual at a given time, there is great potential to use this information to tailor interventional strategies specifically to the metabolic needs of the individual. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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