Two different methods to assess sympathetic tone during general anesthesia lead to different findings.

Noxious stimulation influences the autonomic nervous system activity. Sympathetic tone monitoring is currently used to assess the adequacy of the balance between nociception and anti-nociception during general anesthesia. The Surgical Plethysmographic Index (SPI) and the EBMi software (Custos©) are...

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Published in:Journal of Clinical Monitoring & Computing Vol. 33; no. 3; pp. 463 - 470
Main Authors: Defresne, Aline, Harrison, Michael, Clement, François, Barvais, Luc, Bonhomme, Vincent
Format: research Journal Article
Published: Springer Nature Jun2019
Online Access:View this record in EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: Two different methods to assess sympathetic tone during general anesthesia lead to different findings.
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        au:
          Defresne, Aline
          Harrison, Michael
          Clement, François
          Barvais, Luc
          Bonhomme, Vincent
        affil: GIGA – Consciousness, Anesthesia and Intensive Care Medicine Laboratory, University and CHU University Hospital of Liege, Liege, Belgium
      sug:
        subj:
          Sympathetic Nervous System Physiopathology
          Anesthesia, General
          Intraoperative Monitoring Methods
          Plethysmography Methods
          Blood Pressure Drug Effects
          Autonomic Nervous System
          Equipment Design
          Retrospective Design
          Software
          Heart Rate
          Anesthetics, Intravenous Pharmacodynamics
          Propofol Pharmacodynamics
          Algorithms
          Anesthetics
          Perception
          Human
          Validation Studies
          Comparative Studies
          Evaluation Research
          Multicenter Studies
          Questionnaires
          Scales
      ab: Noxious stimulation influences the autonomic nervous system activity. Sympathetic tone monitoring is currently used to assess the adequacy of the balance between nociception and anti-nociception during general anesthesia. The Surgical Plethysmographic Index (SPI) and the EBMi software (Custos©) are commercial devices that use different algorithms to measure it. We aimed at determining whether those devices provide similar information during routine surgical procedures under general anesthesia. Data acquired during a previously published study in patients undergoing surgery under general anesthesia were retrospectively analyzed and passed through the EBMi software. The occurrence of EBMi alarms of increased sympathetic tone was compared to the occurrence of SPI values ≥ 60, a commonly recommended intraoperative SPI threshold. Trends in classical parameters of sympathetic tone during the 5 min preceding a SPI ≥ 60, namely blood pressure, heart rate, and plethysmographic pulse amplitude were assessed. SPI ≥ 60 episodes (n = 307) were more frequent than EBMi alerts (n = 240). Approximately 70% of EBMi alerts occurred during periods where the SPI was below 60. Among all episodes of SPI ≥ 60, absence of any EBMi alerts was much more frequent than the inverse. A majority, but not all SPI ≥ 60 episodes were consistently preceded by an increase in heart rate and/or a decrease in pulse amplitude. Blood pressure did not significantly change before SPI ≥ 60. Longer SPI ≥ 60 episodes were associated with lower anti-nociception anesthetic regimen. Different methods of sympathetic tone assessment during general anesthesia provide conflicting information. Prospective studies should be undertaken to clarify the clinical indications of both techniques.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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