Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing.
Engineered microscale hydrogels have emerged as promising therapeutic approaches for the treatment of various diseases. These microgels find wide application in the biomedical field because of the ease of injectability, controlled release of therapeutics, flexible means of synthesis, associated tuna...
| Publicado en: | Biomedical Microdevices Vol. 21; no. 2 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136256470&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136256470 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872176 ODN jtl: Biomedical Microdevices issn: 13872176 maglogo: N pubinfo: dt: Jun2019 vid: 21 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136256470 10.1007/s10544-019-0358-0 136256470 ppct: 1 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing. aug: au: Wechsler, Marissa E. Stephenson, Regan E. Murphy, Andrew C. Oldenkamp, Heidi F. Singh, Ankur Peppas, Nicholas A. affil: Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA sug: ab: Engineered microscale hydrogels have emerged as promising therapeutic approaches for the treatment of various diseases. These microgels find wide application in the biomedical field because of the ease of injectability, controlled release of therapeutics, flexible means of synthesis, associated tunability, and can be engineered as stimuli-responsive. While bulk hydrogels of several length-scale dimensions have been used for over two decades in drug delivery applications, their use as microscale carriers of drug and cell-based therapies is relatively new. Herein, we critically summarize the fundamentals of hydrogels based on their equilibrium and dynamics of their molecular structure, as well as solute diffusion as it relates to drug delivery. In addition, examples of common microgel synthesis techniques are provided. The ability to tune microscale hydrogels to obtain controlled release of therapeutics is discussed, along with microgel considerations for cell encapsulation as it relates to the development of cell-based therapies. We conclude with an outlook on the use of microgels for cell sequencing, and the convergence of the use of microscale hydrogels for drug delivery, cell therapy, and cell sequencing based systems. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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