Large-scale validation of an automatic EEG arousal detection algorithm using different heterogeneous databases.

Objective: To assess the validity of an automatic EEG arousal detection algorithm using large patient samples and different heterogeneous databases.Methods: Automatic scorings were confronted with results from human expert scorers on a total of 2768 full-night PSG recordings obtained from two differ...

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Publicado en:Sleep Medicine Vol. 57; pp. 6 - 15
Autores principales: Alvarez-Estevez, Diego, Fernández-Varela, Isaac
Formato: research tables/charts Journal Article
Publicado: Elsevier B.V. May2019
Acceso en línea:Ver este registro en EBSCOhost
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      dt: May2019
      vid: 57
      pid: 467
      pub: Elsevier B.V.
      place: New York, New York
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        136349344
        136349344
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        136349344
        10.1016/j.sleep.2019.01.025
        NLM30878899
        136349344
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        atl: Large-scale validation of an automatic EEG arousal detection algorithm using different heterogeneous databases.
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        au:
          Alvarez-Estevez, Diego
          Fernández-Varela, Isaac
        affil: Sleep Center and Clinical Neurophysiology Department, Haaglanden Medisch Centrum, The Hague, The Netherlands
      sug:
        subj:
          Algorithms
          Sleep Physiology
          Resource Databases
          Electroencephalography
          Middle Age
          Human
          Polysomnography
          Arousal
          Reproducibility of Results
          Female
          Aged
          Male
          Validation Studies
          Comparative Studies
          Evaluation Research
          Multicenter Studies
          Middle Aged: 45-64 years
          Aged: 65+ years
          Female
          Male
      ab: Objective: To assess the validity of an automatic EEG arousal detection algorithm using large patient samples and different heterogeneous databases.Methods: Automatic scorings were confronted with results from human expert scorers on a total of 2768 full-night PSG recordings obtained from two different databases. Of them, 472 recordings were obtained during a clinical routine at our sleep center and were subdivided into two subgroups of 220 (HMC-S) and 252 (HMC-M) recordings each, according to the procedure followed by the clinical expert during the visual review (semi-automatic or purely manual, respectively). In addition, 2296 recordings from the public SHHS-2 database were evaluated against the respective manual expert scorings.Results: Event-by-event epoch-based validation resulted in an overall Cohen's kappa agreement of κ = 0.600 (HMC-S), 0.559 (HMC-M), and 0.573 (SHHS2). Estimated inter-scorer variability on the datasets was, respectively, κ = 0.594, 0.561 and 0.543. Analyses of the corresponding Arousal Index scores showed associated automatic-human repeatability indices ranges of 0.693-0.771 (HMC-S), 0.646-0.791 (HMC-M), and 0.759-0.791 (SHHS2).Conclusions: Large-scale validation of our automatic EEG arousal detector on different databases has shown robust performance and good generalization results comparable to the expected levels of human agreement. Special emphasis was put on reproducibility of the results; implementation of our method has been made available online as open source code.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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