Gray matter reduction related to decreased serum creatinine and increased triglyceride, Hemoglobin A1C, and low-density lipoprotein in subjects with obesity.
Purpose: Altered brain volume and metabolic variables have been found in subjects with obesity. However, the role of metabolic parameters in gray matter volume (GMV) has been poorly investigated. This study aimed to investigate the relationship between the metabolic parameters and brain volume in su...
| Publicado en: | Neuroradiology Vol. 61; no. 6; pp. 703 - 711 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136405238&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136405238 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jun2019 vid: 61 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136405238 136405238 136405238 10.1007/s00234-019-02202-3 136405238 ppf: 703 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Gray matter reduction related to decreased serum creatinine and increased triglyceride, Hemoglobin A1C, and low-density lipoprotein in subjects with obesity. aug: au: Shan, Han Li, Panlong Liu, Hua Nie, Binbin Yin, Xiaolong Zhang, Tianhao Sun, Xi Zhang, Wei Feng, Ting Wang, Luying Hu, Yichao Dong, Guanglong Gao, Hongkai Du, Jin Ma, Lin Li, Demin Shan, Baoci affil: Department of Radiology, Chinese People's Liberation Army General Hospital, 100853, Beijing, China sug: subj: Gray Matter Pathology Creatinine Blood Triglycerides Blood Glycated Hemoglobin Blood Lipoproteins, LDL Blood Obesity Metabolism Obesity Surgery Human Age Factors Sex Factors Gastrectomy Methods Prospective Studies Magnetic Resonance Imaging Methods Diagnosis, Brain Methods Multiple Linear Regression Cognition Parietal Lobe Physiopathology Occipital Lobe Physiopathology Cerebellum Physiopathology Weight Loss Recovery Postoperative Period ab: Purpose: Altered brain volume and metabolic variables have been found in subjects with obesity. However, the role of metabolic parameters in gray matter volume (GMV) has been poorly investigated. This study aimed to investigate the relationship between the metabolic parameters and brain volume in subjects with obesity. Methods: Thirty-seven subjects with obesity and 39 age and sex matched normal-weight controls were included in this study. Eighteen of the 37 participants who underwent sleeve gastrectomy were included in the longitudinal analysis. Blood samples and high-resolution 3T T1-weighted magnetic resonance images were collected. Metabolic parameters in plasma and GMV were measured. Results: Multiple linear regression analysis showed that gray matter reduction in several cognition-related cortices including right angular gyrus, superior occipital cortex, superior parietal cortex, and cerebellum was related to decreased creatinine, as well as increased triglyceride, HbA1c, and low-density lipoprotein in plasma in subjects with obesity. Weight loss after the surgery induced significant recovery of altered metabolic parameters and decreased gray matter volume. Furthermore, changes in the four metabolic parameters before and after the surgery were associated with changes in gray matter volume. Conclusion: Our results suggest that the gray matter reduction is related to decreased creatinine as well as increased triglyceride, HbA1c, and low-density lipoprotein in plasma in subjects with obesity. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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