Accuracy of Intraoperative Examination in Central Nervous System Lesions: A Study of 133 Cases.
Objective: Intraoperative examination is a highly valuable tool for the evaluation of central nervous system (CNS) lesions, helping the neurosurgeon to determine the best surgical management. This study aimed to evaluate the accuracy and to analyze the diagnostic disagreements and pitfalls of the in...
| Publicado en: | Acta Cytologica Vol. 63; no. 3; pp. 224 - 233 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Karger AG
2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136617328&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136617328 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00015547 10OE jtl: Acta Cytologica issn: 00015547 maglogo: N pubinfo: dt: 2019 vid: 63 iid: 3 pid: 2485 pub: Karger AG artinfo: ui: 136617328 146761826 10.1159/000495175 136617328 ppf: 224 ppct: 9 formats: tig: atl: Accuracy of Intraoperative Examination in Central Nervous System Lesions: A Study of 133 Cases. aug: au: Balsimelli, Ludmila Barbosa de Souza Oliveira, Jamille Costa de Adorno, Flora Ávila Brites, Clarissa Almeida Bublitz, Giuliano Stefanello Tavares, Lara Cristina de Carvalho Coelho, Karina Munhoz de Paula Alves Stall, Jaqueline França, Paulo Henrique Condeixa de affil: Pathology Residency Program, Hospital Municipal São José, Joinville, Brazil sug: subj: Intraoperative Care Central Nervous System Diseases Diagnosis Central Nervous System Diseases Pathology Histological Techniques Methods Cytodiagnosis Methods Predictive Value of Tests Diagnostic Errors Human Validity Retrospective Design World Health Organization Neoplasm Grading Frozen Sections Record Review Neoplasm Metastasis Sampling Error Central Nervous System Neoplasms Diagnosis Sensitivity and Specificity ab: Objective: Intraoperative examination is a highly valuable tool for the evaluation of central nervous system (CNS) lesions, helping the neurosurgeon to determine the best surgical management. This study aimed to evaluate the accuracy and to analyze the diagnostic disagreements and pitfalls of the intraoperative examinations through correlation with the final histopathological diagnosis in CNS lesions. Study Design: Retrospective analysis of intraoperative examination of CNS lesions and their final diagnosis obtained during 16 consecutive years. All diagnoses were reviewed and classified according to World Health Organization (WHO) grading for CNS tumors. Squash was performed in 119 cases, while frozen section and both methods were done in 7 cases each. Results: Among the 133 intraoperative examinations considered, 114 (85.7%) presented concordance and 19 (14.3%) diagnostic disagreement when compared with subsequent histopathological examinations. The sensitivity and specificity for the detection of neoplasia in intraoperative examination was 98 and 94%, respectively. The positive and negative predictive values were 99 and 88%, respectively. The accuracy for neoplastic and nonneoplastic disease was 85.7%. Disagreements were more frequent among low-grade (WHO grades I and II) neoplasms and nonmalignant cases. Conclusions: Our results showed good accuracy of the intraoperative assessments for diagnosis of CNS lesions, particularly in high-grade (grades III and IV) lesions and metastatic neoplasms. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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