Predicting survival in patients with recurrent symptomatic malignant pleural effusions: an assessment of the prognostic values of physiologic, morphologic, and quality of life measures of extent of disease.
Purpose: To determine the prognostic value of pleural fluid pH, pleural fluid glucose, extent of pleural carcinomatosis (EPC) score, and Karnofsky Performance Scale (KPS) score in patients with recurrent symptomatic malignant pleural effusions.Design: Prospective 53-month study.Setting: Referral cen...
| Published in: | CHEST Vol. 117; no. 1; pp. 73 - 79 |
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| Main Authors: | , , |
| Format: | research Journal Article |
| Published: |
American College of Chest Physicians
2000 Jan
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136636874&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136636874 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00123692 1G4 jtl: CHEST issn: 00123692 maglogo: N pubinfo: dt: 2000 Jan vid: 117 iid: 1 pid: 2556 pub: American College of Chest Physicians place: Glenview, Illinois artinfo: ui: 136636874 136636874 NLM10631202 136636874 10.1378/chest.117.1.73 NLM10631202 136636874 ppf: 73 ppct: 6 formats: tig: atl: Predicting survival in patients with recurrent symptomatic malignant pleural effusions: an assessment of the prognostic values of physiologic, morphologic, and quality of life measures of extent of disease. aug: au: Burrows, C M Mathews, W C Colt, H G affil: University of California at San Diego Medical Center, San Diego, CA, USA sug: subj: Quality of Life Pleural Effusion, Malignant Mortality Body Fluids Metabolism Aged, 80 and Over Male Pleurodesis Aged Talc Administration and Dosage Neoplasm Recurrence, Local Prospective Studies Pleural Effusion, Malignant Metabolism Adult Thoracoscopy Pleural Effusion, Malignant Therapy Hydrogen-Ion Concentration Middle Age Human Karnofsky Performance Status Pleural Effusion, Malignant Pathology Glucose Metabolism Prognosis Female Survival Validation Studies Comparative Studies Evaluation Research Multicenter Studies Ferrans and Powers Quality of Life Index Aged, 80 & over Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: To determine the prognostic value of pleural fluid pH, pleural fluid glucose, extent of pleural carcinomatosis (EPC) score, and Karnofsky Performance Scale (KPS) score in patients with recurrent symptomatic malignant pleural effusions.Design: Prospective 53-month study.Setting: Referral center for interventional pulmonology.Patients: Eighty-five consecutive patients (42 men and 43 women) with recurrent symptomatic malignant pleural effusions who were referred to the interventional pulmonary service for thoracoscopic pleurodesis.Measurements: Pleural fluid pH, pleural fluid glucose, EPC score, and KPS score.Results: The KPS score was the only statistically significant predictor variable. Patients with a KPS score >/= 70 had a median survival of 395 days, as opposed to a median survival of only 34 days for patients with a KPS score </= 30. No prognostic advantage was evident when patients were categorized by pleural fluid pH, pleural fluid glucose, or EPC score.Conclusion: When assessing the prognosis of a patient with a recurrent symptomatic malignant pleural effusion, only the KPS score at the time of thoracoscopy is predictive of survival. Pleural fluid pH, pleural fluid glucose, and EPC scores are not as reliable as initially reported. For patients with a KPS score >/= 70, it may be very reasonable to proceed with thoracoscopic talc pleurodesis for management of their malignant pleural effusions. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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