Fatigue and declines in cognitive functioning in multiple sclerosis.
Objective: To determine whether cognitive fatigue, defined as a decline in cognitive performance over a single testing session, could be identified in MS.Methods: Forty-five individuals with MS and 14 healthy control participants completed a 4-hour session of cognitive testing that involved a baseli...
| Publicado en: | Neurology Vol. 55; no. 7; pp. 934 - 940 |
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| Autores principales: | , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2000 Oct 10
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136638006&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136638006 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283878 NRO jtl: Neurology issn: 00283878 maglogo: N pubinfo: dt: 2000 Oct 10 vid: 55 iid: 7 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 136638006 136638006 NLM11061247 136638006 10.1212/wnl.55.7.934 NLM11061247 136638006 ppf: 934 ppct: 6 formats: tig: atl: Fatigue and declines in cognitive functioning in multiple sclerosis. aug: au: Krupp, L B Elkins, L E affil: (Department of Neurology, State University of New York at Stony Brook, 11794-8121, USA sug: subj: Multiple Sclerosis Physiopathology Multiple Sclerosis Psychosocial Factors Fatigue Physiopathology Cognition Fatigue Psychosocial Factors Adult Neuropsychological Tests Male Predictive Value of Tests Female Middle Age Self Assessment Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objective: To determine whether cognitive fatigue, defined as a decline in cognitive performance over a single testing session, could be identified in MS.Methods: Forty-five individuals with MS and 14 healthy control participants completed a 4-hour session of cognitive testing that involved a baseline neuropsychological battery, a continuous effortful cognitive task (completing mental arithmetic problems administered on a computer), and a repeat neuropsychological battery. Self-report measures of fatigue and affect were completed before each step of the testing session.Results: The pattern of change in cognitive performances over the testing session significantly differed between the MS and control participants. Individuals with MS showed declines on measures of verbal memory and conceptual planning, whereas the control participants showed improvement. Although there were no significant differences between the groups on any of the baseline cognitive measures, the MS participants performed worse than the control subjects on tests of visual memory, verbal memory, and verbal fluency that were repeated following the continuous effortful cognitive task. Both MS and control participants reported increased mental and physical fatigue across the testing session compared with their baseline values.Conclusion: Individuals with MS show declines in cognitive performance during a single testing session and fail to show the improvement exemplified by healthy control subjects. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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