Thalidomide-induced neuropathy.
Background: Thalidomide is effective for the treatment of some refractory dermatologic and oncologic diseases. Toxic neuropathy limits its use, as embryopathy can be avoided by contraceptive measures.Objective: To describe the clinical, electrophysiologic, and pathologic features of thalidomide-indu...
| Publicado en: | Neurology Vol. 59; no. 12; pp. 1872 - 1876 |
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| Autores principales: | , , , , , |
| Formato: | case study clinical trial research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2002 Dec 24
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136640040&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136640040 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283878 NRO jtl: Neurology issn: 00283878 maglogo: N pubinfo: dt: 2002 Dec 24 vid: 59 iid: 12 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 136640040 136640040 NLM12499476 136640040 10.1212/01.wnl.0000037480.59194.85 NLM12499476 136640040 ppf: 1872 ppct: 4 formats: tig: atl: Thalidomide-induced neuropathy. aug: au: Chaudhry, V Cornblath, D R Corse, A Freimer, M Simmons-O'Brien, E Vogelsang, G affil: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA sug: subj: Neurotoxicity Syndromes Pathology Thalidomide Adverse Effects Immunosuppressive Agents Adverse Effects Thalidomide Therapeutic Use Tibial Nerve Pathology Middle Age Immunosuppressive Agents Therapeutic Use Female Human Neural Conduction Drug Effects Neurologic Examination Neuropsychological Tests Neurotoxicity Syndromes Physiopathology Sensation Disorders Physiopathology Sensation Disorders Chemically Induced Graft Versus Host Disease Prevention and Control Bone Marrow Transplantation Male Paresthesia Chemically Induced Adult Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Background: Thalidomide is effective for the treatment of some refractory dermatologic and oncologic diseases. Toxic neuropathy limits its use, as embryopathy can be avoided by contraceptive measures.Objective: To describe the clinical, electrophysiologic, and pathologic features of thalidomide-induced peripheral neuropathy.Methods: Clinical and electrophysiologic examinations were performed in seven patients with thalidomide-induced peripheral neuropathy. Thalidomide was used for graft-vs-host disease, pyoderma gangrenosum, and discoid lupus with dosages ranging from 100 to 1,200 mg/day for 5 to 16 months (cumulative dosages of 24 to 384 g).Results: All seven patients had clinical and electrophysiologic evidence of a sensory more than motor, axonal, length-dependent polyneuropathy that presented as painful paresthesias or numbness. Sural nerve biopsies, done in three patients, showed evidence of Wallerian degeneration and loss of myelinated fibers. The symptoms, signs, and electrophysiologic data correlated with total cumulative dose of thalidomide.Conclusions: Thalidomide induces a dose-dependent sensorimotor length-dependent axonal neuropathy; it should be judiciously used with close neurologic monitoring. pubtype: Academic Journal doctype: case study clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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