SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies.
The authors recently have shown that triplication of the alpha-synuclein gene (SNCA) can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. The authors assessed 101 familial PD probands, 325 sporadic PD cases, 65 patients with dementia with Lewy bodies, and 366 neuro...
| Publicado en: | Neurology Vol. 63; no. 3; pp. 554 - 557 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2004 Aug 10
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136640987&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136640987 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283878 NRO jtl: Neurology issn: 00283878 maglogo: N pubinfo: dt: 2004 Aug 10 vid: 63 iid: 3 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 136640987 136640987 NLM15304594 136640987 10.1212/01.wnl.0000133401.09043.44 NLM15304594 136640987 ppf: 554 ppct: 3 formats: tig: atl: SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies. aug: au: Johnson, J Hague, S M Hanson, M Gibson, A Wilson, K E Evans, E W Singleton, A A McInerney-Leo, A Nussbaum, R L Hernandez, D G Gallardo, M McKeith, I G Burn, D J Ryu, M Hellstrom, O Ravina, B Eerola, J Perry, R H Jaros, E Tienari, P affil: Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA sug: subj: Nerve Tissue Proteins Parkinson Disease Lewy Body Disease Mutation Lewy Body Disease Epidemiology White Persons United States Female Sequence Analysis England Adult Parkinson Disease Epidemiology Disease Susceptibility Middle Age Nerve Tissue Proteins Physiology Genes Hispanic Americans Human Finland Aged, 80 and Over Male Genotype Prospective Studies Aged Family Health Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Female Male ab: The authors recently have shown that triplication of the alpha-synuclein gene (SNCA) can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. The authors assessed 101 familial PD probands, 325 sporadic PD cases, 65 patients with dementia with Lewy bodies, and 366 neurologically normal control subjects for SNCA multiplication. The authors did not identify any subjects with multiplication of SNCA and conclude this mutation is a rare cause of disease. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|