Epidemiology of ossification of the spinal ligaments and associated factors in the Chinese population: a cross-sectional study of 2000 consecutive individuals.
Background: The epidemiology and cause of ossification of the spinal ligaments (OSL) remains obscure. To date, there is no study that comprehensively evaluates the prevalence, distribution, and concomitance of each type of OSL by CT among general Chinese population. We therefore aimed to comprehensi...
| Publicado en: | BMC Musculoskeletal Disorders Vol. 20; no. 1; pp. 1 - 13 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
5/25/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136662417&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136662417 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712474 1CI5 jtl: BMC Musculoskeletal Disorders issn: 14712474 maglogo: N pubinfo: dt: 5/25/2019 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 136662417 136662417 NLM31128588 10.1186/s12891-019-2569-1 NLM31128588 136662417 ppf: 1 ppct: 12 formats: tig: atl: Epidemiology of ossification of the spinal ligaments and associated factors in the Chinese population: a cross-sectional study of 2000 consecutive individuals. aug: au: Liang, Haifeng Liu, Guobing Lu, Shunyi Chen, Shuguang Jiang, Dongjie Shi, Hongcheng Fei, Qinming affil: Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Building 1, 180 Fenglin Road, 200032, Shanghai, People's Republic of China sug: subj: Ligaments, Articular Pathology Hyperostosis, Diffuse Idiopathic Skeletal Epidemiology Spine Pathology Ossification, Heterotopic Epidemiology China Male Hyperostosis, Diffuse Idiopathic Skeletal Pathology Adult Prevalence Risk Factors Ossification, Heterotopic Diagnosis Middle Age Hyperostosis, Diffuse Idiopathic Skeletal Ligaments, Articular Retrospective Design Female Ossification, Heterotopic Pathology Cross Sectional Studies Spine Incidence Questionnaires Scales Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: The epidemiology and cause of ossification of the spinal ligaments (OSL) remains obscure. To date, there is no study that comprehensively evaluates the prevalence, distribution, and concomitance of each type of OSL by CT among general Chinese population. We therefore aimed to comprehensively investigate epidemiological characteristics of OSL using whole spine CT in the Chinese population and examine the factors that correlate with the presence of OSL.Methods: Ossification of the posterior longitudinal ligament (OPLL), ligamentum flavum (OLF), anterior longitudinal ligament (OALL), nuchal ligament (ONL), and diffuse idiopathic skeletal hyperostosis (DISH) were evaluated from the subjects who underwent PET/CT for the purpose of cancer screening in our hospital. Prevalence, distribution, and concomitance of OSL were reviewed. Logistic regression analysis was performed to identify the risk factors of OSL.Results: A total of 2000 subjects (1335 men and 665 women) were included. The prevalence rate of cervical OPLL (C-OPLL) was 4.1%, thoracic OPLL (T-OPLL) 2.25%, lumbar OPLL (L-OPLL) 0.8%, thoracic OLF (T-OLF) 37.65%, lumbar OLF (L-OLF) 1.45%, ONL 31.5%, DISH 3.85%. The most commonly involved level was C5 for C-OPLL, T1 for T-OPLL, T10 for T-OLF, and T8/9 for OALL. 21% of subjects with C-OPLL had T-OPLL, 44% of C-OPLL had T-OLF, 38% of T-OPLL had C-OPLL, 53% of T-OPLL had T-OLF, 44% of L-OPLL had T-OPLL, and 56% of L-OPLL had T-OLF. The average age of OSL-positive subjects was significantly higher than that of OSL-negative subjects. The results of the multiple regression analysis revealed that males had a strong association with DISH (odds ratio, 3.15; 95% confidence interval, 1.27-7.78; P = 0.013).Conclusion: The prevalence of OSL in the Chinese was revealed. Tandem ossification is not uncommon in people with OSL. There is a high incidence of multiple-regional OPLL in the whole spine. Approximately half of the subjects with OPLL coexist with T-OLF. For patients with clinical symptoms induced by OPLL, thorough evaluation of whole spine using CT is recommended. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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