Decreased cortical and subcortical response to inhibition control after sleep deprivation.
The effects of sleep deprivation (SD) on the neural substrates of inhibition control are poorly understood. Here we used functional magnetic resonance imaging to examine the effects of 24 h of SD on cerebral activation during a stop-signal task in 20 normal young subjects. Behaviorally, subjects sho...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 3; pp. 638 - 651 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136693229&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136693229 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2019 vid: 13 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136693229 136693229 NLM29748772 10.1007/s11682-018-9868-2 NLM29748772 136693229 ppf: 638 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Decreased cortical and subcortical response to inhibition control after sleep deprivation. aug: au: Zhao, Rui Zhang, Xinxin Fei, Ningbo Zhu, Yuanqiang Sun, Jinbo Liu, Peng Yang, Xuejuan Qin, Wei affil: Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, 710071, Shaan xi, China sug: subj: Sleep Deprivation Physiopathology Reaction Time Physiology Behavior Magnetic Resonance Imaging Psychomotor Performance Frontal Lobe Physiology Male Female Adolescence Image Processing, Computer Assisted Methods Young Adult Dominance, Cerebral Brain Mapping Methods Clinical Assessment Tools Adolescent: 13-18 years Male Female ab: The effects of sleep deprivation (SD) on the neural substrates of inhibition control are poorly understood. Here we used functional magnetic resonance imaging to examine the effects of 24 h of SD on cerebral activation during a stop-signal task in 20 normal young subjects. Behaviorally, subjects showed significantly delayed stop-signal reaction time (SSRT) following SD. In addition, reduced cerebral activation was found in the "stopping network" (including the inferior frontal gyrus [IFG], supplementary motor area, subthalamic nucleus [STN] and insula) and vision-related regions (occipital cortex, lingual gyrus and fusiform gyrus) after SD. These findings support the hypothesis that task-related activation in prefrontal cortex is particularly vulnerable to SD. After rested wakefulness (RW), significant negative correlations were found between SSRT and cerebral activation in left IFG, right hippocampus, right lingual gyrus, left STN and bilateral fusiform gyrus, with activation in left IFG making the most contribution. After SD, significant negative correlations were found between SSRT and activation in right middle frontal cortex, right IFG and left lingual gyrus, with the activation in right IFG making the most contribution. Furthermore, we observed significant interaction effects of state (SD or RW) with activation in bilateral IFG, left STN and left lingual gyrus on SSRT. In conclusion, sleep deprivation is associated with the deficits in inhibition-related neural activation and the altered correlation between SSRT and cerebral activation, especially in the bilateral IFG, left STN and left lingual gyrus. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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