Reduced hemispheric asymmetry of brain anatomical networks in attention deficit hyperactivity disorder.
Despite many studies reporting a variety of alterations in brain networks in patients with attention deficit hyperactivity disorder (ADHD), alterations in hemispheric anatomical networks are still unclear. In this study, we investigated topology alterations in hemispheric white matter in patients wi...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 3; pp. 669 - 685 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136693237&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136693237 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2019 vid: 13 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136693237 136693237 NLM29752654 136693237 10.1007/s11682-018-9881-5 NLM29752654 136693237 ppf: 669 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Reduced hemispheric asymmetry of brain anatomical networks in attention deficit hyperactivity disorder. aug: au: Li, Dandan Li, Ting Niu, Yan Xiang, Jie Cao, Rui Liu, Bo Zhang, Hui Wang, Bin affil: College of Information and Computer, Taiyuan University of Technology, No. 79, Yingze West Street, 030024, Taiyuan, Shanxi, China sug: subj: Brain Physiology Attention Deficit Hyperactivity Disorder Physiopathology Image Processing, Computer Assisted Methods Neural Pathways Physiology Dominance, Cerebral Physiology Female Magnetic Resonance Imaging Methods Nervous System Brain Mapping Methods Intelligence Tests Male Adult Middle Age Scales Funding Source Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Despite many studies reporting a variety of alterations in brain networks in patients with attention deficit hyperactivity disorder (ADHD), alterations in hemispheric anatomical networks are still unclear. In this study, we investigated topology alterations in hemispheric white matter in patients with ADHD and the relationship between these alterations and clinical features of the illness. Weighted hemispheric brain anatomical networks were first constructed for each of 40 right-handed patients with ADHD and 53 matched normal controls. Then, graph theoretical approaches were utilized to compute hemispheric topological properties. The small-world property was preserved in the hemispheric network. Furthermore, a significant group-by-hemisphere interaction was revealed in global efficiency, local efficiency and characteristic path length, attributed to the significantly reduced hemispheric asymmetry of global and local integration in patients with ADHD compared with normal controls. Specifically, reduced asymmetric regional efficiency was found in three regions. Finally, we found that the abnormal asymmetry of hemispheric brain anatomical network topology and regional efficiency were both associated with clinical features (the Adult ADHD Self-Report Scale and Wechsler Adult Intelligence Scale) in patients. Our findings provide new insights into the lateralized nature of hemispheric dysconnectivity and highlight the potential for using brain network measures of hemispheric asymmetry as neural biomarkers for ADHD and its clinical features. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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