Aberrant topological organization of the functional brain network associated with prior overt hepatic encephalopathy in cirrhotic patients.
A higher risk of cognitive impairments has been found after an overt hepatic encephalopathy (OHE) episode in cirrhotic patients. We investigated the effect of prior OHE episodes on the topological organization of the functional brain network and its association with the relevant cognitive impairment...
| Published in: | Brain Imaging & Behavior Vol. 13; no. 3; pp. 771 - 781 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Jun2019
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136693245&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136693245 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2019 vid: 13 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136693245 136693245 NLM29846883 10.1007/s11682-018-9896-y NLM29846883 136693245 ppf: 771 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Aberrant topological organization of the functional brain network associated with prior overt hepatic encephalopathy in cirrhotic patients. aug: au: Chen, Hua-Jun Chen, Qiu-Feng Yang, Zhe-Ting Shi, Hai-Bin affil: Department of Radiology, Fujian Medical University Union Hospital, 350001, Fuzhou, China sug: subj: Liver Cirrhosis Physiopathology Hepatic Encephalopathy Physiopathology Female Adult Psychometrics Brain Mapping Methods Nervous System Physiopathology Hepatic Encephalopathy Complications Male Magnetic Resonance Imaging Methods Liver Cirrhosis Complications Middle Age Brain Physiopathology Limbic System Physiopathology Clinical Assessment Tools Scales Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: A higher risk of cognitive impairments has been found after an overt hepatic encephalopathy (OHE) episode in cirrhotic patients. We investigated the effect of prior OHE episodes on the topological organization of the functional brain network and its association with the relevant cognitive impairments. Resting-state functional MRI data were acquired from 41 cirrhotic patients (19 with prior OHE (Prior-OHE) and 22 without (Non-Prior-OHE)) and 21 healthy controls (HC). A Psychometric Hepatic Encephalopathy Score (PHES) assessed cognition. The whole-brain functional network was constructed by thresholding functional correlation matrices of 90 brain regions (derived from the Automated Anatomic Labeling atlas). The topological properties of the brain network, including small-worldness, network efficiency, and nodal efficiency, were examined using graph theory-based analysis. Globally, the Prior-OHE group had a significantly decreased clustering coefficient and local efficiency, compared with the controls. Locally, the nodal efficiency in the bilateral medial superior frontal gyrus and the right postcentral gyrus decreased in the Prior-OHE group, while the nodal efficiency in the bilateral anterior cingulate/paracingulate gyri and right superior parietal gyrus increased in the Prior-OHE group. The alterations of global and regional network parameters progressed from Non-Prior-OHE to Prior-OHE and the clustering coefficient and local efficiency values were significantly correlated with PHES results. In conclusion, cirrhosis leads to the reduction of brain functional network efficiency, which could be aggravated by a prior OHE episode. Aberrant topological organization of the functional brain network may contribute to a higher risk of cognitive impairments in Prior-OHE patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|