Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques.
Renal fibrosis is a useful biomarker for diagnosis and guidance of therapeutic interventions of chronic kidney disease (CKD), a worldwide disease that affects more than 10% of the population and is one of the major causes of death. Currently, tissue biopsy is the gold standard for assessment of rena...
| Publicado en: | Translational Research: The Journal of Laboratory & Clinical Medicine Vol. 209; pp. 105 - 121 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jul2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136712040&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136712040 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19315244 2Q66 jtl: Translational Research: The Journal of Laboratory & Clinical Medicine issn: 19315244 maglogo: N pubinfo: dt: Jul2019 vid: 209 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 136712040 136712040 NLM31082371 136712040 10.1016/j.trsl.2019.02.009 NLM31082371 136712040 ppf: 105 ppct: 16 formats: tig: atl: Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques. aug: au: Jiang, Kai Ferguson, Christopher M. Lerman, Lilach O. affil: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota sug: subj: Kidney Pathology Kidney Ultrasonography Magnetic Resonance Imaging Fibrosis Human Oxygen Blood Clinical Assessment Tools Scales ab: Renal fibrosis is a useful biomarker for diagnosis and guidance of therapeutic interventions of chronic kidney disease (CKD), a worldwide disease that affects more than 10% of the population and is one of the major causes of death. Currently, tissue biopsy is the gold standard for assessment of renal fibrosis. However, it is invasive, and prone to sampling error and observer variability, and may also result in complications. Recent advances in diagnostic imaging techniques, including magnetic resonance imaging (MRI) and ultrasonography, have shown promise for noninvasive assessment of renal fibrosis. These imaging techniques measure renal fibrosis by evaluating its impacts on the functional, mechanical, and molecular properties of the kidney, such as water mobility by diffusion MRI, tissue hypoxia by blood oxygenation level dependent MRI, renal stiffness by MR and ultrasound elastography, and macromolecule content by magnetization transfer imaging. Other MR techniques, such as T1/T2 mapping and susceptibility-weighted imaging have also been explored for measuring renal fibrosis. Promising findings have been reported in both preclinical and clinical studies using these techniques. Nevertheless, limited specificity, sensitivity, and practicality in these techniques may hinder their immediate application in clinical routine. In this review, we will introduce methodologies of these techniques, outline their applications in fibrosis imaging, and discuss their limitations and pitfalls. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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