The diagnosis and treatment of urogenital schistosomiasis in Italy in a retrospective cohort of immigrants from Sub-Saharan Africa.
Objectives: To evaluate ultrasound and praziquantel to, respectively, assess and reduce urogenital schistosomiasis (UGS)-associated morbidity in migrants from Sub-Saharan Africa (SSA). Methods: Migrants from SSA with UGS attending three Italian centres for tropical diseases during 2011–2016 were ret...
| Publicado en: | Infection Vol. 47; no. 3; pp. 447 - 460 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136714644&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136714644 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Jun2019 vid: 47 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136714644 136714644 136714644 10.1007/s15010-019-01270-0 136714644 ppf: 447 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The diagnosis and treatment of urogenital schistosomiasis in Italy in a retrospective cohort of immigrants from Sub-Saharan Africa. aug: au: Tilli, Marta Rinaldi, Francesca Bartoloni, Alessandro Zammarchi, Lorenzo Minervini, Andrea Carini, Marco Sforza, Simone Gobbi, Federico Buonfrate, Dora Degani, Monica Bisoffi, Zeno Testa, Jacopo Caligaris, Silvio Magro, Paola Gulletta, Maurizio Castelli, Francesco Tuccio, Agostino Agostini, Simone Parretti, Filippo Richter, Joachim affil: Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy sug: subj: Immigrants Male Urogenital Diseases Female Urogenital Diseases Schistosomiasis Ultrasonography Schistosomiasis Prevention and Control Isoquinolines Administration and Dosage Morbidity Prevention and Control Human Italy Retrospective Design Africa South of the Sahara Parasitology Descriptive Statistics Health Behavior Algorithms Multicenter Studies ab: Objectives: To evaluate ultrasound and praziquantel to, respectively, assess and reduce urogenital schistosomiasis (UGS)-associated morbidity in migrants from Sub-Saharan Africa (SSA). Methods: Migrants from SSA with UGS attending three Italian centres for tropical diseases during 2011–2016 were retrospectively enrolled. Data on clinical symptoms, routine laboratory, parasitological tests, and ultrasound reported as per the WHO–Niamey protocol were collected at baseline and at available follow-up visits after treatment with praziquantel 40 mg/kg/day for 3 days. Results: One hundred and seventy patients with UGS were enrolled and treated with praziquantel. Baseline ultrasonography showed urinary tract abnormalities in 115/169 patients (68%); the mean global Schistosoma haematobium score was 2.29 (SD 2.84, IQR 0–2), the mean urinary bladder intermediate score 1.75 (SD 1.73, IQR 0–2), and the mean upper urinary tract intermediate score 0.54 (SD 2.37, IQR 1–10). Abnormalities were more common among the 111 (65%) who were symptomatic (p < 0.02; OR 2.53; 95% CI 1.19–5.35). Symptoms started in 94/111 (85%) before arriving (median 63 months, IQR 12–119). At follow-up, we observed a significant reduction in the prevalence of UGS-related symptoms, blood, urine, and ultrasound abnormalities. Conclusions: Our study results support the use of ultrasound and praziquantel for assessing and reducing UGS-associated morbidity in migrants. Health-seeking behaviour, diagnostic, and treatment delays contribute to the advanced pathology and qualified treatment success. To ensure earlier treatment, based on our findings, clinical experience, and available literature, we propose an algorithm for the diagnosis and clinical management of UGS. Multicentre studies are needed to improve the management of subjects with UGS in non-endemic countries. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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