Maternal psychological distress during pregnancy and childhood cardio-metabolic risk factors.
Background and Aims: Previous studies suggest that psychological distress during pregnancy may lead to fetal developmental adaptations, which programme cardio-metabolic disease of the offspring. We examined the associations of maternal overall psychological distress, depression and anxiety during pr...
| Publicado en: | Nutrition, Metabolism & Cardiovascular Diseases Vol. 29; no. 6; pp. 572 - 580 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136728677&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136728677 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09394753 1F3L jtl: Nutrition, Metabolism & Cardiovascular Diseases issn: 09394753 maglogo: N pubinfo: dt: Jun2019 vid: 29 iid: 6 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 136728677 136728677 NLM30956027 136728677 10.1016/j.numecd.2019.02.008 NLM30956027 136728677 ppf: 572 ppct: 8 formats: tig: atl: Maternal psychological distress during pregnancy and childhood cardio-metabolic risk factors. aug: au: Silva, C.C.V. Vehmeijer, F.O.L. El Marroun, H. Felix, J.F. Jaddoe, V.W.V. Santos, S. affil: Erasmus MC, University Medical Center Rotterdam, The Generation R Study Group, Rotterdam, the Netherlands sug: subj: Stress, Psychological Epidemiology Triglycerides Blood Anxiety Epidemiology Prenatal Exposure Delayed Effects Depression Epidemiology Heart Rate Mothers Psychosocial Factors Netherlands Stress, Psychological Psychosocial Factors Sex Factors Stress, Psychological Diagnosis Risk Factors Risk Assessment Young Adult Blood Pressure Age Factors Prospective Studies C-Reactive Protein Analysis Male Anxiety Diagnosis Blood Glucose Analysis Depression Psychosocial Factors Human Female Child Adult Pregnancy Anxiety Psychosocial Factors Depression Diagnosis Insulin Blood Validation Studies Comparative Studies Evaluation Research Multicenter Studies Brief Symptom Inventory Child: 6-12 years Adult: 19-44 years Male Female ab: Background and Aims: Previous studies suggest that psychological distress during pregnancy may lead to fetal developmental adaptations, which programme cardio-metabolic disease of the offspring. We examined the associations of maternal overall psychological distress, depression and anxiety during pregnancy with cardio-metabolic risk factors in 10-year-old children and explore potential sex-specific differences.Methods and Results: In a population-based prospective cohort study among 4,088 mothers and their children, information about overall psychological distress, including depression and anxiety was obtained through the Brief Symptom Inventory during pregnancy. We measured child blood pressure and heart rate and insulin, glucose, serum lipids and C-reactive protein blood concentrations at 10 years. Analyses were performed in the total group and in boys and girls separately. Psychological distress during pregnancy was associated with higher childhood heart rate among boys only (differences 0.34 (95% Confidence Interval (CI) 0.18, 0.50) standard deviation scores (SDS), 0.22 (95% CI 0.06, 0.38) SDS, 0.33 (95% CI 0.19, 0.48) SDS, for overall psychological distress, depression and anxiety, respectively). Maternal anxiety during pregnancy was associated with higher childhood triglycerides among girls (difference 0.35 (95% CI 0.17, 0.53) SDS). Maternal psychological distress was not associated with childhood blood pressure, cholesterol, insulin, glucose and C-reactive protein concentrations.Conclusions: Maternal psychological distress may influence their offspring heart rate and triglycerides concentrations. Further studies are needed to replicate these findings and assess the long-term cardio-metabolic consequences of maternal psychological distress. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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