Altered brain diffusion tensor imaging indices in adolescents with the Fontan palliation.
Purpose: Single ventricle heart disease (SVHD) patients show injury in brain sites that regulate autonomic, mood, and cognitive functions. However, the nature (acute or chronic changes) and extent of brain injury in SVHD are unclear. Our aim was to examine regional brain tissue damage in SVHD over c...
| Publicado en: | Neuroradiology Vol. 61; no. 7; pp. 811 - 825 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136828397&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136828397 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jul2019 vid: 61 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136828397 136828397 136828397 10.1007/s00234-019-02208-x 136828397 ppf: 811 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered brain diffusion tensor imaging indices in adolescents with the Fontan palliation. aug: au: Singh, Sadhana Roy, Bhaswati Pike, Nancy Daniel, Ebenezer Ehlert, Luke Lewis, Alan B. Halnon, Nancy Woo, Mary A. Kumar, Rajesh affil: Department of Anesthesiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, 56-141 CHS, 10833 Le Conte Aves, 90095-1763, Los Angeles, CA, USA sug: subj: Heart Ventricle Surgery Heart Defects, Congenital Surgery Magnetic Resonance Imaging Methods Brain Injuries In Adolescence Human Neuroradiography Adolescence Affect Cognition Analysis of Covariance Telencephalon Neural Pathways Temporal Lobe Frontal Lobe Hypothalamus Thalamus Cerebellum Amygdala Adolescent: 13-18 years ab: Purpose: Single ventricle heart disease (SVHD) patients show injury in brain sites that regulate autonomic, mood, and cognitive functions. However, the nature (acute or chronic changes) and extent of brain injury in SVHD are unclear. Our aim was to examine regional brain tissue damage in SVHD over controls using DTI-based mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) procedures. Methods: We collected two DTI series (3.0-T MRI), mood and cognitive data, from 27 SVHD and 35 control adolescents. Whole-brain MD, AD, RD, and FA maps were calculated from each series, realigned and averaged, normalized to a common space, smoothed, and compared between groups using ANCOVA (covariates, age and sex; false discovery rate, p < 0.05). Region-of-interest analyses were performed to calculate MD, AD, RD, and FA values for magnitude assessment between groups. Results: SVHD patients showed impaired mood and cognitive functions over healthy adolescents. Multiple brain sites in SVHD showed increased MD values, including the insula, caudate, cingulate, hypothalamus, thalamus, medial prefrontal and frontal cortices, parahippocampal gyrus, hippocampus, precentral gyrus, amygdala, cerebellum, corpus callosum, basal forebrain, mammillary bodies, internal capsule, midbrain, fornix, and occipital, parietal, and temporal cortices, indicating chronic tissue changes. Similar areas showed either increased AD or RD values, with RD changes more enhanced over AD in SVHD compared to controls. Few brain regions emerged with increased or decreased FA values in SVHD patients over controls. Conclusion: SVHD adolescents, more than a decade from their last surgical procedure, show widespread brain abnormalities in autonomic, mood, and cognitive regulatory areas. These findings indicate that brain injury is in a chronic stage in SVHD with predominantly myelin changes that may result from previous hypoxia/ischemia- or developmental-induced processes. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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