LPHN3 gene variations and susceptibility to ADHD in Chinese Han population: a two-stage case–control association study and gene–environment interactions.
Polymorphisms in latrophilin 3 (LPHN3) were recently reported to be associated with attention-deficit/hyperactivity disorder (ADHD), and subsequently other researchers tried to replicate the findings in different populations. This study was aimed to confirm the role of the LPHN3 in ADHD and explore...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 28; no. 6; pp. 861 - 874 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136861734&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136861734 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jun2019 vid: 28 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136861734 136861734 136861734 10.1007/s00787-018-1251-8 136861734 ppf: 861 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: LPHN3 gene variations and susceptibility to ADHD in Chinese Han population: a two-stage case–control association study and gene–environment interactions. aug: au: Huang, Xin Zhang, Qi Gu, Xue Hou, Yuwei Wang, Min Chen, Xinzhen Wu, Jing affil: Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13, Hangkong Road, 430030, Wuhan, People's Republic of China sug: subj: Polymorphism, Genetic Disease Susceptibility Attention Deficit Hyperactivity Disorder Familial and Genetic Attention Deficit Hyperactivity Disorder Risk Factors Chinese Persons Human China Case Control Studies Attention Deficit Hyperactivity Disorder Diagnosis Questionnaires Lead Blood Spectrophotometry Methods Parental Attitudes Instrument Validation Odds Ratio Confidence Intervals Maternal Attitudes Stress, Psychological Gene Expression Quantitative Studies Child Child: 6-12 years ab: Polymorphisms in latrophilin 3 (LPHN3) were recently reported to be associated with attention-deficit/hyperactivity disorder (ADHD), and subsequently other researchers tried to replicate the findings in different populations. This study was aimed to confirm the role of the LPHN3 in ADHD and explore the potential interactions with environmental risk factors in Chinese Han population. We examined the association of LPHN3 with ADHD in a population of 473 ADHD children and 585 controls. As a supplement of ADHD diagnosis, Conners Parent Symptom Questionnaire (PSQ) was used to evaluate ADHD symptoms. Blood lead levels (BLLs) were measured by atomic absorption spectrophotometry and other potential environmental risk factors were determined via a questionnaire filled out by the parents. Finally, after validation in an independent sample (284 cases and 390 controls), we observed significant associations between LPHN3 variants rs1868790 and ADHD risk in combined stage within codominant model [TA/AA: OR (95% CI) = 1.636 (1.325–2.021)], dominant model [OR (95% CI) = 1.573 (1.288–1.922)], and additive model [OR (95% CI) = 1.535 (1.266–1.862)]. Furthermore, rs1868790 significantly interacted with BLLs and maternal stress to modify ADHD susceptibility (P < 0.05), and rs1868790 was found to be related with ADHD symptoms (P < 0.05). Expression quantitative trait loci analysis further indicated that rs1868790 took part in the regulation of LPHN3 gene expression. As the first study to comprehensively explore the role of LPHN3 in ADHD in Chinese children, our research suggests that LPHN3 gene has a significant effect on the ADHD in a Chinese population. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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