The efficacy of a hydroxyapatite composite as a biodegradable antibiotic delivery system.
Local biodegradable carriers have been studied for use as a skeletal drug delivery system. This study investigated the efficacy of a local biodegradable composite composed of hydroxyapatite, plaster of Paris, and chitosan impregnated with antibiotics to treat methicillin-resistant Staphylococcus aur...
| Publicado en: | Clinical Orthopaedics & Related Research® Vol. 2004; no. 424; pp. 244 - 253 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Jul2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136867142&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136867142 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0009921X 23N jtl: Clinical Orthopaedics & Related Research® issn: 0009921X maglogo: N pubinfo: dt: Jul2004 vid: 2004 iid: 424 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 136867142 136867142 NLM15241172 136867142 NLM15241172 136867142 ppf: 244 ppct: 9 formats: tig: atl: The efficacy of a hydroxyapatite composite as a biodegradable antibiotic delivery system. aug: au: Buranapanitkit, Boonsin Srinilta, Vorawat Ingviga, Natnicha Oungbho, Kwunchit Geater, Alan Ovatlarnporn, Chitchamai affil: Department of Orthopaedic Surgery and Physical Medicine, Prince of Songkla University, Haadyai, Songkhla 90110, Thailand sug: subj: Biocompatible Materials Minerals Polysaccharides Calcium Compounds Staphylococcal Infections Drug Therapy Antibiotics Administration and Dosage Microscopy, Electron, Scanning Drug Delivery Systems Validation Studies Comparative Studies Evaluation Research Multicenter Studies Interview Guides ab: Local biodegradable carriers have been studied for use as a skeletal drug delivery system. This study investigated the efficacy of a local biodegradable composite composed of hydroxyapatite, plaster of Paris, and chitosan impregnated with antibiotics to treat methicillin-resistant Staphylococcus aureus. The composite, impregnated with vancomycin, fosfomycin, or sodium fusidate was tested for its sustained elution characteristics during 3 months and compared with similarly impregnated polymethylmethacrylate using the modified disc diffusion technique. Physicochemical properties using scanning electron microscopy and xray diffraction analysis of each preparation also were analyzed. Vancomycin and fosfomycin incorporated into the hydroxyapatite composite inhibited the organism for 3 months, whereas sodium fusidate was effective only for 3 weeks. Vancomycin and fosfomycin loaded into the hydroxyapatite composite had a significantly better inhibitive effect than when loaded in polymethylmethacrylate, whereas sodium fusidate loaded in polymethylmethacrylate showed a significantly better inhibitive effect than when loaded in the hydroxyapatite composite. Scanning electron microscopy and xray diffraction analysis elucidated the patterns of each drug release profile. The local hydroxyapatite composite is a promising local biodegradable delivery system for vancomycin and fosfomycin, whereas PMMA is a better carrier for sodium fusidate in treating methicillin-resistant staphylococcus aureus osteomyelitis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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