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The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus.

This study aimed to investigate the association of serum hsCRP and urinary A1MG in patients with T2DM. Numerous investigations have proven that serum hypersensitive C-reactive protein (hsCRP) concentration in patients with type 2 diabetes mellitus (T2DM) is increased. Also, increased urinary alpha-1...

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Published in:BioMed Research International pp. 1 - 11
Main Authors: Wan, Xiaohua, Zhang, Lin, Gu, Haitong, Wang, Shenglai, Liu, Xiangyi
Format: research tables/charts Journal Article
Published: Wiley-Blackwell 6/9/2019
Online Access:View this record in EBSCOhost
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        23146133
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      jtl: BioMed Research International
      issn: 23146133
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    pubinfo:
      dt: 6/9/2019
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        136873510
        136873510
        136873510
        10.1155/2019/6364390
        136873510
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        atl: The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus.
      aug:
        au:
          Wan, Xiaohua
          Zhang, Lin
          Gu, Haitong
          Wang, Shenglai
          Liu, Xiangyi
        affil: Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China
      sug:
        subj:
          Diabetes Mellitus, Type 2 Complications
          C-Reactive Protein Blood
          Serum Globulins Urine
          Diabetic Patients
          Risk Assessment
          Diabetic Nephropathies Risk Factors
          Human
          Renal Insufficiency Risk Factors
          Creatinine Urine
          Immunoglobulins Urine
          Transferrin Urine
          Odds Ratio
          Confidence Intervals
          Logistic Regression
      ab: This study aimed to investigate the association of serum hsCRP and urinary A1MG in patients with T2DM. Numerous investigations have proven that serum hypersensitive C-reactive protein (hsCRP) concentration in patients with type 2 diabetes mellitus (T2DM) is increased. Also, increased urinary alpha-1 microglobulin (A1MG) can be an early sign of renal damage, primarily on the proximal tubules in T2DM. Little information is available with respect to the associations of serum hsCRP levels and urinary A1MG in T2DM. A total of 520 patients with T2DM were recruited to participate in this study. Serum hsCRP and UA1MG (urinary alpha1-microglobulin to creatinine ratio), UACR (urinary microalbumin to creatinine ratio), UIGG (urinary immunoglobulin G to creatinine ratio), and UTRF (urinary transferrin to creatinine ratio) were obtained. The association of serum hsCRP level and each urinary protein parameter was analyzed by using the regression analysis, respectively. LnhsCRP was positively associated with the lnUA1MG in all three linear regression models (adjusted β in model 3=0.122, SE=0.027, P<0.001). Furthermore, the high hsCRP group (hsCRP > 3mg/L) was associated with increasing risk of high UA1MG (adjusted OR in model 3=1.610, 95% CI 1.037–2.499, P=0.034) by logistic regression. This study suggests that serum hsCRP levels independently associate with UA1MG in patients with T2DM. Further research is warranted to elucidate these interactions.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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