Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial.
Purpose: In obesity and diabetes the liver is highly susceptible to abnormal uptake and storage of fat. In certain individuals hepatic steatosis predisposes to the development of non-alcoholic steatohepatitis (NASH), a disease marked by hepatic inflammation and fibrosis. Although the precise pathoph...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 4; pp. 1735 - 1746 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=136938812&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 136938812 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Jun2019 vid: 58 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 136938812 136938812 136938812 10.1007/s00394-018-1721-2 136938812 ppf: 1735 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial. aug: au: Bomhof, Marc R. Parnell, Jill A. Ramay, Hena R. Crotty, Pam Rioux, Kevin P. Probert, Chris S. Jayakumar, Saumya Raman, Maitreyi Reimer, Raylene A. affil: Department of Kinesiology and Physical Education, University of Lethbridge, 4401 University Drive, T1K 3M4, Lethbridge, AB, Canada sug: subj: Dietary Supplementation Prebiotics Therapeutic Use Nonalcoholic Fatty Liver Disease Diet Therapy Nonalcoholic Fatty Liver Disease Diagnosis Human Randomized Controlled Trials Pilot Studies Biopsy Methods Treatment Outcomes Body Weight Changes Body Composition Glucose Tolerance Test Inflammation Biological Markers Gut Microbiota Weight Loss Fructose Bifidobacterium Clostridium Life Style Changes ab: Purpose: In obesity and diabetes the liver is highly susceptible to abnormal uptake and storage of fat. In certain individuals hepatic steatosis predisposes to the development of non-alcoholic steatohepatitis (NASH), a disease marked by hepatic inflammation and fibrosis. Although the precise pathophysiology of NASH is unknown, it is believed that the gut microbiota-liver axis influences the development of this disease. With few treatment strategies available for NASH, exploration of gut microbiota-targeted interventions is warranted. We investigated the therapeutic potential of a prebiotic supplement to improve histological parameters of NASH. Methods: In a placebo-controlled, randomized pilot trial, 14 individuals with liver-biopsy-confirmed NASH [non-alcoholic fatty liver activity score (NAS) ≥ 5] were randomized to receive oligofructose (8 g/day for 12 weeks followed by 16 g/day for 24 weeks) or isocaloric placebo for 9 months. The primary outcome measure was the change in liver biopsy NAS score and the secondary outcomes included changes in body weight, body composition, glucose tolerance, inflammatory markers, and gut microbiota. Results: Independent of weight loss, oligofructose improved liver steatosis relative to placebo and improved overall NAS score (P = 0.016). Bifidobacterium was enhanced by oligofructose, whereas bacteria within Clostridium cluster XI and I were reduced with oligofructose (P < 0.05). There were no adverse side effects that deterred individuals from consuming oligofructose for treatment of this disease. Conclusions: Independent of other lifestyle changes, prebiotic supplementation reduced histologically-confirmed steatosis in patients with NASH. Larger follow-up studies are warranted. Clinical Trial: This trial was registered at Clinicaltrials.com as NCT03184376. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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