Dopamine manipulations drive changes in information sampling in healthy volunteers.
Background: Information sampling is the cognitive process of accumulating information before committing to a decision. Patients across numerous disorders show decreased information sampling relative to controls.Aims: Here, we used the Beads and the Best Choice Tasks to study the role of dopamine sig...
| Publicado en: | Journal of Psychopharmacology Vol. 33; no. 6; pp. 670 - 678 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137001492&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137001492 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02698811 3FD jtl: Journal of Psychopharmacology issn: 02698811 maglogo: Y pubinfo: dt: Jun2019 vid: 33 iid: 6 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 137001492 137001492 NLM30644326 137001492 10.1177/0269881118822080 NLM30644326 137001492 ppf: 670 ppct: 8 formats: tig: atl: Dopamine manipulations drive changes in information sampling in healthy volunteers. aug: au: Vicario-Feliciano, Raquel Averbeck, Bruno B Wigton, Rebekah L Shergill, Sukhi S White, Thomas P affil: Laboratory of Neuropsychology, National Institutes of Health (NIH), Bethesda, MD, USA sug: subj: Decision Making Drug Effects Dopamine Metabolism Dopamine Antagonists Therapeutic Use Research Subjects Female Indoles Therapeutic Use Basal Ganglia Metabolism Crossover Design Receptors, Cell Surface Metabolism Double-Blind Studies Adult Male Basal Ganglia Drug Effects Validation Studies Comparative Studies Evaluation Research Multicenter Studies Arthritis Impact Measurement Scales Funding Source Human Adult: 19-44 years Female Male ab: Background: Information sampling is the cognitive process of accumulating information before committing to a decision. Patients across numerous disorders show decreased information sampling relative to controls.Aims: Here, we used the Beads and the Best Choice Tasks to study the role of dopamine signaling in information sampling.Methods: Participants were given placebo, amisulpride, or ropinirole in each session, in a double-blind cross-over design.Results: We found that ropinirole (agonist) increased the number of beads drawn in the Beads Task specifically when participants faced a loss, and decreased the rank of the chosen option in the Best Choice Task.Conclusions: These effects are likely driven by a combination of effects at presynaptic D2 receptors, which affect dopamine release, and post-synaptic D2 receptors. Increased D2 relative to D1 receptor activation in the striatum leads to increased sampling in the loss condition in the Beads Task. It also leads to choice of a poorer ranked option in the Best Choice Task. Decreased D2 relative to D1 receptor activation leads to decreased sampling in the Beads Task in the loss condition. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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