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Mining heterogeneous network for drug repositioning using phenotypic information extracted from social media and pharmaceutical databases.

Drug repositioning has drawn significant attention for drug development in pharmaceutical research and industry, because of its advantages in cost and time compared with the de novo drug development. The availability of biomedical databases and online health-related information, as well as the high-...

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Published in:Artificial Intelligence in Medicine Vol. 96; pp. 80 - 93
Main Authors: Yang, Christopher C., Zhao, Mengnan
Format: research tables/charts Journal Article
Published: Elsevier B.V. May2019
Online Access:View this record in EBSCOhost
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      dt: May2019
      vid: 96
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      pub: Elsevier B.V.
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        10.1016/j.artmed.2019.03.003
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        atl: Mining heterogeneous network for drug repositioning using phenotypic information extracted from social media and pharmaceutical databases.
      aug:
        au:
          Yang, Christopher C.
          Zhao, Mengnan
        affil: College of Computing and Informatics, Drexel University, Philadelphia, PA, United States
      sug:
        subj:
          Drug Repositioning
          Data Mining Methods
          Social Media
          Databases
          Human
          Adverse Drug Event Epidemiology
          Validation Studies
          Comparative Studies
          Evaluation Research
          Multicenter Studies
      ab: Drug repositioning has drawn significant attention for drug development in pharmaceutical research and industry, because of its advantages in cost and time compared with the de novo drug development. The availability of biomedical databases and online health-related information, as well as the high-performance computing, empowers the development of computational drug repositioning methods. In this work, we developed a systematic approach that identifies repositioning drugs based on heterogeneous network mining using both pharmaceutical databases (PharmGKB and SIDER) and online health community (MedHelp). By utilizing adverse drug reactions (ADRs) as the intermediate, we constructed a heterogeneous health network containing drugs, diseases, and ADRs, and developed path-based heterogeneous network mining approaches for drug repositioning. Additionally, we investigated on how the data sources affect the performance on drug repositioning. Experiment results showed that combining both PharmKGB and MedHelp identified 479 repositioning drugs, which are more than the repositioning drugs discovered by other alternatives. In addition, 31% of the 479 of the discovered repositioning drugs were supported by evidence from PubMed.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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