Body site-dependent variations of microbiota in pancreatic cancer pathophysiology.
Lack of specific symptoms and reliable biomarkers, along with aggressive nature and resistance to therapies makes pancreatic cancer (PC) one of the leading causes of death from cancer worldwide. The search for new diagnostic, prognostic, predictive, and therapeutic tools that could improve clinical...
| Publicado en: | Critical Reviews in Clinical Laboratory Sciences Vol. 56; no. 4; pp. 260 - 274 |
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| Autores principales: | , |
| Formato: | pictorial review Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137143963&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137143963 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10408363 1AV jtl: Critical Reviews in Clinical Laboratory Sciences issn: 10408363 maglogo: Y pubinfo: dt: Jun2019 vid: 56 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 137143963 137143963 137143963 10.1080/10408363.2019.1615407 137143963 ppf: 260 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Body site-dependent variations of microbiota in pancreatic cancer pathophysiology. aug: au: Panebianco, Concetta Pazienza, Valerio affil: Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy sug: subj: Pancreatic Neoplasms Physiopathology Microbiota Physiology Biological Markers Homeostasis Helicobacter Pylori Pancreatic Neoplasms Prognosis ab: Lack of specific symptoms and reliable biomarkers, along with aggressive nature and resistance to therapies makes pancreatic cancer (PC) one of the leading causes of death from cancer worldwide. The search for new diagnostic, prognostic, predictive, and therapeutic tools that could improve clinical outcomes of patients has led, in recent years, to the investigation of potential roles for the microbiota in the pathogenesis of this disease. The human microbiota encompasses trillions of microorganisms residing within several body tissues and organs, where they provide beneficial functions for host homeostasis and health. Derangements of the microbial ecology in different anatomic districts have been described in PC, as in many other diseases, both in patients and in animal models. In detail, infection from the gastric pathogen Helicobacter pylori and changes in composition and diversity of oral, intestinal, and pancreatic microbiota have been found to associate with PC. Future research should assess how to potentially exploit such differences in microbiota composition as diagnostic, prognostic, or predictive biomarkers, and as targets for therapeutic interventions, in the hope of improving the dismal prognosis of this insidious cancer. pubtype: Academic Journal doctype: pictorial review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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