Biochemical markers of time since death in cerebrospinal fluid: A first step towards "Forensomics".
The accurate estimation of the time of death is a challenge in forensic medicine, as the methods routinely used to assess the postmortem interval (PMI) are far from being precise. Over the past decades, biochemical methods have been implemented on postmortem samples to improve the precision of PMI e...
| Publicado en: | Critical Reviews in Clinical Laboratory Sciences Vol. 56; no. 4; pp. 274 - 287 |
|---|---|
| Autores principales: | , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137143964&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137143964 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10408363 1AV jtl: Critical Reviews in Clinical Laboratory Sciences issn: 10408363 maglogo: Y pubinfo: dt: Jun2019 vid: 56 iid: 4 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 137143964 137143964 137143964 10.1080/10408363.2019.1619158 137143964 ppf: 274 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Biochemical markers of time since death in cerebrospinal fluid: A first step towards "Forensomics". aug: au: Peyron, Pierre-Antoine Lehmann, Sylvain Delaby, Constance Baccino, Eric Hirtz, Christophe affil: Department of Forensic Medicine, Montpellier University Hospital, Montpellier, France sug: subj: Biological Markers Cerebrospinal Fluid Postmortem Changes Diagnosis Cerebrospinal Fluid Analysis Reference Values Biochemistry Forensic Medicine ab: The accurate estimation of the time of death is a challenge in forensic medicine, as the methods routinely used to assess the postmortem interval (PMI) are far from being precise. Over the past decades, biochemical methods have been implemented on postmortem samples to improve the precision of PMI estimation. Studies have focussed on the biochemical profiles of closed compartment body fluids, as they are preserved longer than blood after death and are thus subject to confined postmortem chemical changes. Cerebrospinal fluid (CSF) has been considered a suitable fluid to investigate these changes, as it is found in large amounts and is easy to sample. Moreover, the main molecules found in CSF have known reference values in living subjects, unlike most other body fluids. In this literature review, we focus on the panel of biomarkers that have been studied in CSF based on their potential of offering information on the time of death. The interest in these biomarkers for casework and the research perspectives in this field are discussed. Integrating data from different methods, including biochemistry, for better estimation of the time of death would represent a step forward in the forensic field, paving the way for an innovative approach that we suggest to call "Forensomics." pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|