Patient Preferences Concerning Alternative Treatments for Neuroendocrine Tumors: Results of the "PIANO-Study".
Objectives: Neuroendocrine tumors (NETs) are rare, slow-growing malignant tumors. So far, there are no data on patient preferences regarding its therapy. This empirical study aimed to elicit patient preferences in the drug treatment of NET.Methods: Based on qualitative patient interviews and an anal...
| Publicado en: | International Journal of Technology Assessment in Health Care Vol. 35; no. 3; pp. 243 - 252 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137169198&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137169198 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02664623 FZY jtl: International Journal of Technology Assessment in Health Care issn: 02664623 maglogo: N pubinfo: dt: 2019 vid: 35 iid: 3 pid: 15979 pub: Cambridge University Press artinfo: ui: 137169198 137169198 NLM31044688 137169198 10.1017/S0266462319000217 NLM31044688 137169198 ppf: 243 ppct: 9 formats: tig: atl: Patient Preferences Concerning Alternative Treatments for Neuroendocrine Tumors: Results of the "PIANO-Study". aug: au: Mühlbacher, Axel C. Juhnke, Christin affil: Health Economics and Health Care Management, Hochschule Neubrandenburg, Germany sug: subj: Patient Satisfaction Antineoplastic Agents Therapeutic Use Consumer Participation Methods Neuroendocrine Tumors Drug Therapy Decision Making Neuroendocrine Tumors Mortality Female Neoplasm Invasiveness Male Middle Age Adult Antineoplastic Agents Administration and Dosage Neuroendocrine Tumors Pathology Socioeconomic Factors Aged Antineoplastic Agents Adverse Effects Disease Remission Animals Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female Male ab: Objectives: Neuroendocrine tumors (NETs) are rare, slow-growing malignant tumors. So far, there are no data on patient preferences regarding its therapy. This empirical study aimed to elicit patient preferences in the drug treatment of NET.Methods: Based on qualitative patient interviews and an analytic hierarchy process, six patient-relevant attributes were analyzed and weighted using a discrete-choice experiment. Patients were recruited with the help of a NET support group. An experimental 3*3 + 6*3 -MNL design was created using NGene. The design consisted of eighty-four choices, divided into seven blocks. Participants were randomly assigned to these blocks. The analysis included random parameter logit and latent class models.Results: A total of 275 participants (51.6 percent female; mean age, 58.4 years) were included. The preference analysis within the random parameter logit model, taking into account the 95 percent confidence interval, showed predominance for the attribute "overall survival." The attributes "response to treatment" and "stabilization of tumor growth" followed. The side effects "nausea/vomiting" and "diarrhea" were considered of relatively equal importance. Latent class analysis of possible subgroup differences revealed three preference patterns.Conclusions: Preferences can influence therapeutic decisions. Preference analyses indicated that "overall survival" had the strongest influence, with participants clearly weighing outcome attributes higher than side effect attributes. In conclusion, mono-criterial decisions would not fully reflect patient perspectives. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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