The microbiome and cognitive aging: a review of mechanisms.
Gut microbiota plays an intrinsic role in communication between the gut and the brain and is capable of influencing the host brain by producing neurotransmitters and neurotrophins, the modulation of inflammatory processes amongst other key mechanisms. Increased age is also associated with changes in...
| Publicado en: | Psychopharmacology Vol. 236; no. 5; pp. 1559 - 1572 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137228952&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137228952 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: May2019 vid: 236 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137228952 10.1007/s00213-019-05231-1 137228952 ppf: 1559 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The microbiome and cognitive aging: a review of mechanisms. aug: au: Komanduri, Mrudhula Gondalia, Shakuntla Scholey, Andrew Stough, Con affil: Centre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Melbourne, Victoria, Australia sug: ab: Gut microbiota plays an intrinsic role in communication between the gut and the brain and is capable of influencing the host brain by producing neurotransmitters and neurotrophins, the modulation of inflammatory processes amongst other key mechanisms. Increased age is also associated with changes in these key biological processes and impairments in a range of cognitive processes. We hypothesise several mechanisms in which gut microbiota may modulate changes in cognitive function with age. In this review, we discuss issues related to the measurement of cognition in the elderly and in particular outline a standardised model of cognition that could be utilised to better understand cognitive outcomes in future studies examining the relationship between gut microbiota and cognition in the elderly. We then review biological processes such as oxidative stress and inflammation which are related to cognitive changes with age and which are also influenced by our gut microbiota. Finally, we outline other potential mechanisms by which the gut microbiota may influence cognition. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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