The phenolic interactome and gut microbiota: opportunities and challenges in developing applications for schizophrenia and autism.
Schizophrenia and autism spectrum disorder have long been associated with elevated levels of various small phenolic molecules (SPMs). In turn, the gut microbiota (GMB) has been implicated in the kinetics of many of these analytes. Unfortunately, research into the possible relevance of GMB-mediated S...
| Publicado en: | Psychopharmacology Vol. 236; no. 5; pp. 1471 - 1490 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137228958&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137228958 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: May2019 vid: 236 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137228958 10.1007/s00213-019-05267-3 137228958 ppf: 1471 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The phenolic interactome and gut microbiota: opportunities and challenges in developing applications for schizophrenia and autism. aug: au: Jaskiw, George E. Obrenovich, Mark E. Donskey, Curtis J. affil: Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA sug: ab: Schizophrenia and autism spectrum disorder have long been associated with elevated levels of various small phenolic molecules (SPMs). In turn, the gut microbiota (GMB) has been implicated in the kinetics of many of these analytes. Unfortunately, research into the possible relevance of GMB-mediated SPMs to neuropsychiatry continues to be limited by heterogeneous study design, numerous sources of variance and technical challenges. Some SPMs have multiple structural isomers and most have conjugates. Without specialized approaches, SPMs can be incorrectly assigned or inaccurately quantified. In addition, SPM levels can be affected by dietary polyphenol or protein consumption and by various medications and diseases. Nonetheless, heterotypical excretion of various SPMs in association with schizophrenia or autism continues to be reported in independent samples. Recent studies in human cerebrospinal fluid demonstrate the presence of many SPMs A large number of these are bioactive in experimental models. Whether such mechanisms are relevant to the human brain in health or disease is not known. Systematic metabolomic and microbiome studies of well-characterized populations, an appreciation of multiple confounds, and implementation of standardized approaches across platforms and sites are needed to delineate the potential utility of the phenolic interactome in neuropsychiatry. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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