Extracapsular extension on MRI indicates a more aggressive cell cycle progression genotype of prostate cancer.
Purpose: To explore associations between magnetic resonance imaging (MRI) features of prostate cancer and expression levels of cell cycle genes, as assessed by the Prolaris® test. Materials and methods: Retrospective analysis of 118 PCa patients with genetic testing of biopsy specimen and prostate M...
| Publicado en: | Abdominal Radiology Vol. 44; no. 8; pp. 2864 - 2874 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137251588&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137251588 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Aug2019 vid: 44 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137251588 10.1007/s00261-019-02023-1 137251588 ppf: 2864 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Extracapsular extension on MRI indicates a more aggressive cell cycle progression genotype of prostate cancer. aug: au: Wibmer, Andreas G. Robertson, Nicola L. Hricak, Hedvig Zheng, Junting Capanu, Marinela Stone, Steven Ehdaie, Behfar Brawer, Michael K. Vargas, Hebert Alberto affil: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10065, New York, NY, USA sug: ab: Purpose: To explore associations between magnetic resonance imaging (MRI) features of prostate cancer and expression levels of cell cycle genes, as assessed by the Prolaris® test. Materials and methods: Retrospective analysis of 118 PCa patients with genetic testing of biopsy specimen and prostate MRI from 08/2013 to 11/2015. Associations between the cell cycle risk (CCR) score and MRI features [i.e., PI-RADSv2 score, extracapsular extension (ECE), quantitative metrics] were analyzed with Fisher's exact test, nonparametric tests, and Spearman's correlation coefficient. In 41 patients (34.7%), test results were compared to unfavorable features on prostatectomy specimen (i.e., Gleason group ≥ 3, ECE, lymph node metastases). Results: Fifty-four (45.8%), 60 (50.8%), and 4 (3.4%) patients had low-, intermediate-, and high-risk cancers according to American Urological Association scoring system. Patients with ECE on MRI had significantly higher mean CCR scores (reader 1: 3.9 vs. 3.2, p = 0.015; reader 2: 3.6 vs. 3.2, p = 0.045). PI-RADSv2 scores and quantitative MRI features were not associated with CCR scores. In the prostatectomy subset, ECE on MRI (p = < 0.001–0.001) and CCR scores (p = 0.049) were significantly associated with unfavorable histopathologic features. Conclusion: The phenotypic trait of ECE on MRI indicates a more aggressive genotype of prostate cancer. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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