Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders.
Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 49; no. 7; pp. 2664 - 2675 |
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| Autores principales: | , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137289960&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137289960 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jul2019 vid: 49 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137289960 137289960 137289960 10.1007/s10803-016-2803-8 137289960 ppf: 2664 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders. aug: au: Fitzgerald, Jacqueline Gallagher, Louise McGrath, Jane affil: Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland sug: subj: White Matter Anatomy and Histology Autism Spectrum Disorder Diagnosis White Matter Physiopathology Autism Spectrum Disorder Complications Social Behavior Disorders Risk Factors Human Magnetic Resonance Imaging Methods Prospective Studies Intelligence Tests Middle Age Child Adult Young Adult Adolescence Optics Neural Pathways Middle Aged: 45-64 years Child: 6-12 years Adult: 19-44 years Adolescent: 13-18 years ab: Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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