A rapid high-performance semi-automated tool to measure total kidney volume from MRI in autosomal dominant polycystic kidney disease.
Objectives: To develop a high-performance, rapid semi-automated method (Sheffield TKV Tool) for measuring total kidney volume (TKV) from magnetic resonance images (MRI) in patients with autosomal dominant polycystic kidney disease (ADPKD).Methods: TKV was initially measured in 61 patients with ADPKD...
| Publicado en: | European Radiology Vol. 29; no. 8; pp. 4188 - 4198 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137304109&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137304109 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2019 vid: 29 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137304109 137304109 NLM30666443 137304109 10.1007/s00330-018-5918-9 NLM30666443 137304109 ppf: 4188 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A rapid high-performance semi-automated tool to measure total kidney volume from MRI in autosomal dominant polycystic kidney disease. aug: au: Simms, Roslyn J. Doshi, Trushali Metherall, Peter Ryan, Desmond Wright, Peter Gruel, Nicolas van Gastel, Maatje D. A. Gansevoort, Ron T. Tindale, Wendy Ong, Albert C. M. affil: Kidney Genetics Group, Academic Unit of Nephrology, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK sug: subj: Polycystic Kidney, Autosomal Dominant Pathology Kidney Pathology Glomerular Filtration Rate Physiology Disease Progression Adult Young Adult Female Cross Sectional Studies Prognosis Polycystic Kidney, Autosomal Dominant Physiopathology Male Body Weights and Measures Middle Age Magnetic Resonance Imaging Methods Human Retrospective Design Aged Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objectives: To develop a high-performance, rapid semi-automated method (Sheffield TKV Tool) for measuring total kidney volume (TKV) from magnetic resonance images (MRI) in patients with autosomal dominant polycystic kidney disease (ADPKD).Methods: TKV was initially measured in 61 patients with ADPKD using the Sheffield TKV Tool and its performance compared to manual segmentation and other published methods (ellipsoidal, mid-slice, MIROS). It was then validated using an external dataset of MRI scans from 65 patients with ADPKD.Results: Sixty-one patients (mean age 45 ± 14 years, baseline eGFR 76 ± 32 ml/min/1.73 m2) with ADPKD had a wide range of TKV (258-3680 ml) measured manually. The Sheffield TKV Tool was highly accurate (mean volume error 0.5 ± 5.3% for right kidney, - 0.7 ± 5.5% for left kidney), reproducible (intra-operator variability - 0.2 ± 1.3%; inter-operator variability 1.1 ± 2.9%) and outperformed published methods. It took less than 6 min to execute and performed consistently with high accuracy in an external MRI dataset of T2-weighted sequences with TKV acquired using three different scanners and measured using a different segmentation methodology (mean volume error was 3.45 ± 3.96%, n = 65).Conclusions: The Sheffield TKV Tool is operator friendly, requiring minimal user interaction to rapidly, accurately and reproducibly measure TKV in this, the largest reported unselected European patient cohort with ADPKD. It is more accurate than estimating equations and its accuracy is maintained at larger kidney volumes than previously reported with other semi-automated methods. It is free to use, can run as an independent executable and will accelerate the application of TKV as a prognostic biomarker for ADPKD into clinical practice.Key Points: • This new semi-automated method (Sheffield TKV Tool) to measure total kidney volume (TKV) will facilitate the routine clinical assessment of patients with ADPKD. • Measuring TKV manually is time consuming and laborious. • TKV is a prognostic indicator in ADPKD and the only imaging biomarker approved by the FDA and EMA. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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