Transient receptor potential vanilloid (TRPV) channel expression in meningiomas: prognostic and predictive significance.
The TRPV1-4 members of TRPV cation channel subfamily are mainly regarded as polymodal receptors that may be activated by diverse changes in cellular microenvironment and endogenous and exogenous agents. Abnormal expression of these channels has been reported in various tumors but not in meningiomas....
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 475; no. 1; pp. 105 - 115 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jul2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137339395&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137339395 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Jul2019 vid: 475 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137339395 137339395 NLM31119368 137339395 10.1007/s00428-019-02584-y NLM31119368 137339395 ppf: 105 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Transient receptor potential vanilloid (TRPV) channel expression in meningiomas: prognostic and predictive significance. aug: au: Goutsou, Spyridoula Tsakona, Chrisi Polia, Afroditi Moutafidi, Athanasia Zolota, Vassiliki Gatzounis, George Assimakopoulou, Martha affil: Department of Anatomy, Histology and Embryology, School of Medicine, University of Patras, Biomedical Sciences Research Building, 1 Asklipiou, 265 04, Rion, Greece sug: subj: Carrier Proteins Analysis Meningeal Neoplasms Meningioma Aged Aged, 80 and Over Meningeal Neoplasms Mortality Human Adult Cell Physiology Predictive Value of Tests Female Meningeal Neoplasms Therapy Young Adult Meningeal Neoplasms Pathology Meningioma Mortality Middle Age Meningioma Therapy Meningioma Pathology Immunohistochemistry Male Neoplasm Grading Validation Studies Comparative Studies Evaluation Research Multicenter Studies Aged: 65+ years Aged, 80 & over Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: The TRPV1-4 members of TRPV cation channel subfamily are mainly regarded as polymodal receptors that may be activated by diverse changes in cellular microenvironment and endogenous and exogenous agents. Abnormal expression of these channels has been reported in various tumors but not in meningiomas. Meningioma cells are thought to originate from arachnoid cap cells due to cytological and functional similarities between the two types of cells. To investigate the expression profile of TRPV1-4 channels in meningiomas and compare with TRPV1-4 channel expression in leptomeninges, we used immunohistochemistry in formalin-fixed, paraffin-embedded semi-serial tissue sections from 175 meningiomas with different grades and histological subtypes, and normal brain or meningioma specimens that contained leptomeninges. The labeling index (LI), defined as the percentage of positive (labeled) cells out of the total number of tumor cells counted, was determined. Leptomeninges were TRPV1-4 immunonegative. A significant percentage of tumors exhibited TRPV1-4 channel expression which was independent of the proliferation index of the tumors but was significantly associated with histopathological subtypes. The TRPV1 and TRPV3 immunoexpression was decreased whereas TRPV4 immunoexpression was significantly greater in high-grade (WHO, grade II and III) as compared with low-grade (WHO, grade I) meningiomas. Additionally, TRPV4 emerged as an independent predictor for the degree of malignancy using the binary logistic regression model [dependent variable: grade I versus higher grades (II and III)]. Kaplan-Meier analysis for 102 patients showed no significant association of TRPV1-4 expression with overall survival. The above data support that TRPV1-4 channels are implicated in meningioma pathogenesis, and TRPV4 has predictive significance in the disease. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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