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Antibiotic overuse and allergy-related diseases: an epidemiological cross-sectional study in the grasslands of Northern China.

Background: Several studies have shown that the use of antibiotics early in life significantly increases the risk of asthma in children. It is unclear whether antibiotics are more commonly used in patients with allergy-related diseases.Methods: A multistage, clustered and random sampling with a fiel...

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Published in:Therapeutics & Clinical Risk Management Vol. 15; pp. 783 - 790
Main Authors: Chen, Yan Lei, Sng, Weirong Joshua, Wang, De Yun, Wang, Xue Yan
Format: Journal Article
Published: Dove Medical Press Ltd Jun2019
Online Access:View this record in EBSCOhost
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        11766336
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      jtl: Therapeutics & Clinical Risk Management
      issn: 11766336
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      dt: Jun2019
      vid: 15
      pid: 45064
      pub: Dove Medical Press Ltd
      place: Auckland, <Blank>
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        137364264
        137364264
        NLM31417265
        10.2147/TCRM.S203719
        NLM31417265
        137364264
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        atl: Antibiotic overuse and allergy-related diseases: an epidemiological cross-sectional study in the grasslands of Northern China.
      aug:
        au:
          Chen, Yan Lei
          Sng, Weirong Joshua
          Wang, De Yun
          Wang, Xue Yan
      sug:
      ab: Background: Several studies have shown that the use of antibiotics early in life significantly increases the risk of asthma in children. It is unclear whether antibiotics are more commonly used in patients with allergy-related diseases.Methods: A multistage, clustered and random sampling with a field-interviewer-administrated survey study was performed to investigate if there was multiple use of antibiotics (MUA) in patients with allergic rhinitis (AR), conjunctivitis, chronic urticaria (CU), and asthma in the grasslands of northern China. MUA was defined as antibiotic usage for at least 3 days and for more than 3 times a year in the past 2 years.Results: A total of 5,787 subjects completed the study, with 1,079 subjects (18.6%) identified as MUA. MUA was more common in patients with AR (23.7% vs 16.2%, P<0.001), conjunctivitis (22.5% vs 17.1%, P<0.001), asthma (31.8% vs 17.7%, P<0.001), and CU (25.9% vs 18.3%, P<0.01) than in subjects without allergic diseases. There is an increasing percentage of MUA in patients with a single, two, and three or more diseases both in children (20.1%, 25.0%, and 31.4%, respectively, P=0.014) and in adults (19.1%, 23.4%, and 32.9%, respectively, P<0.001). MUA is significantly associated with AR (OR=1.7, 95% CI: 1.3-2.1, P<0.001), conjunctivitis (OR=1.6, 95% CI: 1.2-2.1, P=0.001), asthma (OR=2.3, 95% CI:1.6-3.3, P<0.001) and CU (OR=2.1, 95% CI: 1.2-3.6, P=0.006) in children aged 2-17 years; and in adults (≥18 years old) for AR (OR=1.7, 95% CI: 1.4-2.1, P<0.001), conjunctivitis (OR=1.3, 95% CI:1.1-1.6, P=0.002), and asthma (OR=2.0, 95% CI: 1.5-2.7, P<0.001).Conclusion: Antibiotic overuse might be associated with increased risk of allergy-related disease. It is important that implementation of the evidence-based international guidelines for the management of allergy-related diseases needs to be improved, in order to avoid unnecessary use of antibiotics.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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