Changes in atrial electrophysiological and structural substrate and their relationship to histology in a long‐term chronic canine atrial fibrillation model.
Background: Atrial fibrillation (AF) is related to numerous electrophysiological changes; however, the extent of structural and electrophysiological remodeling with long‐term AF is not well characterized. Methods: Dogs (n = 6) were implanted with a neurostimulator in the right atrium (AF group). No...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 42; no. 7; pp. 930 - 937 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137374797&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137374797 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Jul2019 vid: 42 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 137374797 137374797 137374797 10.1111/pace.13730 137374797 ppf: 930 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Changes in atrial electrophysiological and structural substrate and their relationship to histology in a long‐term chronic canine atrial fibrillation model. aug: au: Yamashita, Kennosuke Silvernagel, Josh Kwan, Eugene Kamali, Roya Ghafoori, Elyar MacLeod, Robert Dosdall, Derek J. Ranjan, Ravi affil: Division of Cardiovascular Medicine, University of Utah, Salt Lake City Utah sug: subj: Electrophysiology Atrial Fibrillation Diagnosis Heart Atrium Anatomy and Histology Heart Atrium Physiology Models, Biological Animal Studies Dogs Chronic Disease Diagnosis Electrodes, Implanted Heart Atrium, Right Surgery Body Surface Potential Mapping Magnetic Resonance Imaging Heart Atrium, Left Anatomy and Histology Heart Atrium, Right Anatomy and Histology ab: Background: Atrial fibrillation (AF) is related to numerous electrophysiological changes; however, the extent of structural and electrophysiological remodeling with long‐term AF is not well characterized. Methods: Dogs (n = 6) were implanted with a neurostimulator in the right atrium (AF group). No implantation was done in the Control group (n = 3). Electroanatomical mapping was done prior to and following more than 6 months of AF. Magnetic resonance imaging was also done to assess structural remodeling. Animals were euthanized and tissue samples were acquired for histological analysis. Results: A significant increase was seen in the left atrial (LA) volume among all AF animals (22.25 ± 12.60 cm3 vs 34.00 ± 12.23 cm3, P = .01). Also, mean bipolar amplitude in the LA significantly decreased from 5.96 ± 2.17 mV at baseline to 3.23 ± 1.51 mV (P < .01) after chronic AF. Those significant changes occurred in each anterior, lateral, posterior, septal, and roof regions as well. Additionally, the dominant frequency (DF) in the LA increased from 7.02 ± 0.37 Hz to 10.12 ± 0.28 Hz at chronic AF (P < .01). Moreover, the percentage of fibrosis in chronic AF animals was significantly larger than that of control animals in each location (P < .01). Conclusions: Canine chronic AF is accompanied by a significant decrease in intracardiac bipolar amplitudes. These decreased electrogram amplitude values are still higher than traditional cut‐off values used for diseased myocardial tissue. Despite these "normal" bipolar amplitudes, there is a significant increase in DF and tissue fibrosis. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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